| Literature DB >> 2904523 |
P J Blankestijn1, A J Man in't Veld, J Tulen, A H van den Meiracker, F Boomsma, P Moleman, H J Ritsema van Eck, F H Derkx, P Mulder, S J Lamberts.
Abstract
In a double blind, crossover study 6 h infusions of adrenaline (15 ng/kg/min; 1 ng = 5.458 pmol), noradrenaline (30 ng/kg/min; 1 ng = 5.911 pmol), and a 5% dextrose solution (5.4 ml/h), were given to ten healthy volunteers in random order 2 weeks apart. By means of intra-arterial ambulatory monitoring the haemodynamic effects were followed for 18 h after the infusions were stopped. Adrenaline, but not noradrenaline, caused a delayed and protracted pressor effect. Over the total postinfusion period systolic and diastolic arterial pressure were 6 (SEM 2)% and 7 (2)%, respectively, higher than after dextrose infusion (ANOVA, p less than 0.001). Thus, "stress" levels of adrenaline (230 pg/ml) for 6 h cause a delayed and protracted pressor effect. These findings are strong support for the adrenaline-hypertension hypothesis in man.Entities:
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Year: 1988 PMID： 2904523 DOI： 10.1016/s0140-6736(88)90585-5
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321