Literature DB >> 29043405

[Focused update on dual antiplatelet treatment : ESC guidelines 2017].

A Schäfer1, J Bauersachs2.   

Abstract

Dual antiplatelet treatment (DAPT) is a cornerstone of maintenance medication of patients following elective percutaneous coronary interventions or an acute coronary syndrome (ACS), e. g. ST elevation myocardial infarction, non-ST elevation myocardial infarction and unstable angina. In recent years the inclusion of P2Y12 inhibition in addition to low-dose acetylsalicylic acid has been intensively debated. Following the introduction of the modern generation of drug-eluting stents for elective coronary interventions, the duration of the necessary DAPT has been clearly reduced. In patients with ACS the question arises when treatment with one of the more potent P2Y12 inhibitors, such as prasugrel and ticagrelor should be used instead of clopidogrel. A potential extension of DAPT beyond 12 months can be considered in high-risk patients after implantation of bioresorbable vascular scaffolds and following myocardial infarction. A special focus is on those patients who have already been treated with oral anticoagulants for stroke prevention in atrial fibrillation and require additional platelet inhibition following coronary stenting. This article summarizes and assesses the major recommendations given in the Focused Update DAPT 2017 of the European Society of Cardiology (ESC). In particular the recommendations address strategies to reduce an increased risk of bleeding based on clinical predictors.

Entities:  

Keywords:  Acute coronary syndrome; Anticoagulation; Dual antiplatelet treatment; P2Y12 blocker; Percutaneous coronary intervention

Mesh:

Substances:

Year:  2017        PMID: 29043405     DOI: 10.1007/s00059-017-4634-6

Source DB:  PubMed          Journal:  Herz        ISSN: 0340-9937            Impact factor:   1.443


  30 in total

1.  Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes.

Authors:  Gilles Montalescot; Leonardo Bolognese; Dariusz Dudek; Patrick Goldstein; Christian Hamm; Jean-Francois Tanguay; Jurrien M ten Berg; Debra L Miller; Timothy M Costigan; Jochen Goedicke; Johanne Silvain; Paolo Angioli; Jacek Legutko; Margit Niethammer; Zuzana Motovska; Joseph A Jakubowski; Guillaume Cayla; Luigi Oltrona Visconti; Eric Vicaut; Petr Widimsky
Journal:  N Engl J Med       Date:  2013-09-01       Impact factor: 91.245

2.  Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.

Authors:  Christopher P Cannon; Deepak L Bhatt; Jonas Oldgren; Gregory Y H Lip; Stephen G Ellis; Takeshi Kimura; Michael Maeng; Bela Merkely; Uwe Zeymer; Savion Gropper; Matias Nordaby; Eva Kleine; Ruth Harper; Jenny Manassie; James L Januzzi; Jurrien M Ten Berg; P Gabriel Steg; Stefan H Hohnloser
Journal:  N Engl J Med       Date:  2017-08-27       Impact factor: 91.245

3.  Two-year outcomes after first- or second-generation drug-eluting or bare-metal stent implantation in all-comer patients undergoing percutaneous coronary intervention: a pre-specified analysis from the PRODIGY study (PROlonging Dual Antiplatelet Treatment After Grading stent-induced Intimal hyperplasia studY).

Authors:  Marco Valgimigli; Matteo Tebaldi; Marco Borghesi; Pascal Vranckx; Gianluca Campo; Carlo Tumscitz; Elisa Cangiano; Monica Minarelli; Antonella Scalone; Caterina Cavazza; Jlenia Marchesini; Giovanni Parrinello
Journal:  JACC Cardiovasc Interv       Date:  2013-12-11       Impact factor: 11.195

4.  Review of article: Rivaroxaban with or without aspirin in stable cardiovascular disease. Eikelboom JW, Connolly SJ, Bosch J, et al. for the COMPASS investigators.

Authors:  Debra Kohlman-Trigoboff
Journal:  J Vasc Nurs       Date:  2017-10-25

5.  Stent Thrombosis and Dual Antiplatelet Therapy Interruption With Everolimus-Eluting Stents: Insights From the Xience V Coronary Stent System Trials.

Authors:  Philippe Généreux; David R Rutledge; Tullio Palmerini; Adriano Caixeta; Elvin Kedhi; James B Hermiller; Jin Wang; Mitchell W Krucoff; Jennifer Jones-McMeans; Krishnankutty Sudhir; Charles A Simonton; Patrick W Serruys; Gregg W Stone
Journal:  Circ Cardiovasc Interv       Date:  2015-05       Impact factor: 6.546

6.  ISAR-SAFE: a randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting.

Authors:  Stefanie Schulz-Schüpke; Robert A Byrne; Jurrien M Ten Berg; Franz-Josef Neumann; Yaling Han; Tom Adriaenssens; Ralph Tölg; Melchior Seyfarth; Michael Maeng; Bernhard Zrenner; Claudius Jacobshagen; Harald Mudra; Eberhard von Hodenberg; Jochen Wöhrle; Dominick J Angiolillo; Barbara von Merzljak; Nonglag Rifatov; Sebastian Kufner; Tanja Morath; Antonia Feuchtenberger; Tareq Ibrahim; Paul W A Janssen; Christian Valina; Yi Li; Walter Desmet; Mohamed Abdel-Wahab; Klaus Tiroch; Christian Hengstenberg; Isabell Bernlochner; Marcus Fischer; Heribert Schunkert; Karl-Ludwig Laugwitz; Albert Schömig; Julinda Mehilli; Adnan Kastrati
Journal:  Eur Heart J       Date:  2015-01-23       Impact factor: 29.983

7.  Clinical impact of gastrointestinal bleeding in patients undergoing percutaneous coronary interventions.

Authors:  Konstantinos C Koskinas; Lorenz Räber; Thomas Zanchin; Peter Wenaweser; Stefan Stortecky; Aris Moschovitis; Ahmed A Khattab; Thomas Pilgrim; Stefan Blöchlinger; Christina Moro; Peter Jüni; Bernhard Meier; Dik Heg; Stephan Windecker
Journal:  Circ Cardiovasc Interv       Date:  2015-05       Impact factor: 6.546

8.  Lack of association between dual antiplatelet therapy use and stent thrombosis between 1 and 12 months following resolute zotarolimus-eluting stent implantation.

Authors:  Sigmund Silber; Ajay J Kirtane; Jorge A Belardi; Minglei Liu; Sandeep Brar; Martin Rothman; Stephan Windecker
Journal:  Eur Heart J       Date:  2014-02-07       Impact factor: 29.983

9.  A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents.

Authors:  A Schömig; F J Neumann; A Kastrati; H Schühlen; R Blasini; M Hadamitzky; H Walter; E M Zitzmann-Roth; G Richardt; E Alt; C Schmitt; K Ulm
Journal:  N Engl J Med       Date:  1996-04-25       Impact factor: 91.245

10.  Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54.

Authors:  Deepak L Bhatt; Marc P Bonaca; Sameer Bansilal; Dominick J Angiolillo; Marc Cohen; Robert F Storey; Kyungah Im; Sabina A Murphy; Peter Held; Eugene Braunwald; Marc S Sabatine; Ph Gabriel Steg
Journal:  J Am Coll Cardiol       Date:  2016-04-01       Impact factor: 24.094

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  2 in total

1.  [Platelet inhibition in elderly patients].

Authors:  A Schäfer; J Bauersachs
Journal:  Herz       Date:  2018-05       Impact factor: 1.443

2.  Efficacy and safety of ticagrelor monotherapy in patients following percutaneous coronary intervention: A systematic review and meta-analysis.

Authors:  Wen-Bin Zhang; Li-Nan Liu; Yang Liu; Zhen Wang
Journal:  Medicine (Baltimore)       Date:  2021-05-21       Impact factor: 1.817

  2 in total

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