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Literature DB >> 29042840

Warfarin-Rifampin Drug Interaction in a Pediatric Patient.

Michael Poon¹, Brady S Moffett¹, Donald L Yee¹.

Abstract

Rifampin has been documented to significantly attenuate the effect of warfarin in adult patients. No data have been presented on the use of rifampin and warfarin in a pediatric patient. We report an extreme case of increased warfarin metabolism in a pediatric patient who was concomitantly receiving rifampin, despite receiving other medications that significantly decrease warfarin metabolism. The inhibitory effect of rifampin on warfarin therapy may be amplified in pediatric patients.

Entities: Chemical Species

Keywords: INR; pediatric; rifampin; warfarin

Year: 2017 PMID： 29042840 PMCID： PMC5640306 DOI： 10.5863/1551-6776-22.5.375

Source DB: PubMed Journal: J Pediatr Pharmacol Ther ISSN： 1551-6776

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References

10 in total

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Warfarin-Rifampin Drug Interaction in a Pediatric Patient.

1. Difficulties in anticoagulation management during coadministration of warfarin and rifampin.

2. Risk factors for elevated INR values during warfarin therapy in hospitalized pediatric patients.

3. Proposal for a new tool to evaluate drug interaction cases.

4. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

5. Inability to achieve a therapeutic INR value while on concurrent warfarin and rifampin.

Review 6. Inability to attain oral anticoagulation: warfarin-rifampin interaction revisited.

7. P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms.

Review 8. Understanding dosing: children are small adults, neonates are immature children.

9. Readmissions for warfarin-related bleeding in pediatric patients after hospital discharge.

10. Describing the profile of patients on concurrent rifampin and warfarin therapy in western Kenya: a case series.