Literature DB >> 2904264

Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver.

M Ingelman-Sundberg1, I Johansson, K E Penttilä, H Glaumann, K O Lindros.   

Abstract

Western blot analysis of digitonin eluates as well as immunohistochemical analysis revealed a 30-fold higher concentration of cytochrome P-450IIE1 in the centrilobular than in the periportal regions of the rat liver. Ethanol treatment caused a selective centrilobular induction of P-450IIE1, whereas phenobarbital induced P-450IIB1/2 in both liver lobule regions. The heterogeneous distribution pattern of P-450IIE1 was also observed in cells isolated from either region and correlated to the relative content of P-450IIE1 mRNA in the two cell types. The regiospecific expression and induction of P-450IIE1 may explain why several hepatotoxins, known to be metabolized by this isozyme, primarily damage the centrilobular region in the liver.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2904264     DOI： 10.1016/s0006-291x(88)80010-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  Zone-specific inducibility of cytochrome P450 2B1/2 is retained in isolated perivenous hepatocytes.

Authors:  R G Bars; D R Bell; C R Elcombe; T Oinonen; T Jalava; K O Lindros
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

2.  High zone-selectivity of cell permeabilization following digitonin-pulse perfusion of rat liver. A re-interpretation of the microcirculatory zones.

Authors:  B Quistorff; P Rømert
Journal:  Histochemistry       Date:  1989

Review 3.  Zonation of hepatic cytochrome P-450 expression and regulation.

Authors:  T Oinonen; K O Lindros
Journal:  Biochem J       Date:  1998-01-01       Impact factor: 3.857

4.  Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern.

Authors:  Jin Wang; Sinead Greene; Lennart C Eriksson; Björn Rozell; Eva Reihnér; Curt Einarsson; Gösta Eggertsen; Mats Gåfvels
Journal:  Histochem Cell Biol       Date:  2005-05-13       Impact factor: 4.304

5.  Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide.

Authors:  E Chieli; M Saviozzi; P Puccini; V Longo; P G Gervasi
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

6.  Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver.

Authors:  T Oinonen; K O Lindros
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

Review 7.  Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms.

Authors:  Magnus Ingelman-Sundberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-10-22       Impact factor: 3.000

8.  Dose-dependent acinar induction of cytochromes P450 in rat liver. Evidence for a differential mechanism of induction of P450IA1 by beta-naphthoflavone and dioxin.

Authors:  R G Bars; C R Elcombe
Journal:  Biochem J       Date:  1991-07-15       Impact factor: 3.857

9.  Role of cysteine and taurine in regulating glutathione synthesis by periportal and perivenous hepatocytes.

Authors:  K E Penttilä
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

10.  Application of key events analysis to chemical carcinogens and noncarcinogens.

Authors:  Alan R Boobis; George P Daston; R Julian Preston; Stephen S Olin
Journal:  Crit Rev Food Sci Nutr       Date:  2009-09       Impact factor: 11.176
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.