Background: Obesity and overweight during pregnancy have been negatively associated with fetal and offspring neurodevelopment. The aim of this systematic review and meta-analysis was to assess the effect of the relationship between pre-pregnancy overweight and obesity with children's neurocognitive development. Methods: We systematically searched MEDLINE, EMBASE, the Cochrane Library and the Web of Science databases from their inception through February 2017 for follow-up studies comparing the relationship between pre-pregnancy weight status and children's cognition. The Mantel-Haenszel fixed-effects method was used to calculate pooled effect size (ES) values and their corresponding 95% confidence intervals (CIs) comparing children's neurocognitive development between pre-pregnancy normal weight, as reference, with overweight and obesity categories. Results: Fifteen articles were included in the systematic review, and nine of them in the meta-analysis. The pooled ES values for overweight and obese mothers were -0.02 (95% CI: -0.05 to 0.02) and -0.06 (95% CI: -0.09 to -0.03), respectively. The pooled ES for the relationship between pre-gestational excess weight (overweight and obesity) and children's neurocognitive development was -0.04 (95% CI: -0.06 to -0.02). Conclusions: Pre-pregnancy obesity might have negative consequences on the neurocognitive development of offspring.
Background: Obesity and overweight during pregnancy have been negatively associated with fetal and offspring neurodevelopment. The aim of this systematic review and meta-analysis was to assess the effect of the relationship between pre-pregnancy overweight and obesity with children's neurocognitive development. Methods: We systematically searched MEDLINE, EMBASE, the Cochrane Library and the Web of Science databases from their inception through February 2017 for follow-up studies comparing the relationship between pre-pregnancy weight status and children's cognition. The Mantel-Haenszel fixed-effects method was used to calculate pooled effect size (ES) values and their corresponding 95% confidence intervals (CIs) comparing children's neurocognitive development between pre-pregnancy normal weight, as reference, with overweight and obesity categories. Results: Fifteen articles were included in the systematic review, and nine of them in the meta-analysis. The pooled ES values for overweight and obese mothers were -0.02 (95% CI: -0.05 to 0.02) and -0.06 (95% CI: -0.09 to -0.03), respectively. The pooled ES for the relationship between pre-gestational excess weight (overweight and obesity) and children's neurocognitive development was -0.04 (95% CI: -0.06 to -0.02). Conclusions: Pre-pregnancy obesity might have negative consequences on the neurocognitive development of offspring.
Authors: Alexa Grudzinski; Leslie Anne Campbell; Lihui Liu; Mary Margaret Brown; Linda Dodds; Stefan Kuhle Journal: Eur Child Adolesc Psychiatry Date: 2019-03-18 Impact factor: 4.785
Authors: Jerod M Rasmussen; Alice M Graham; Lauren E Gyllenhammer; Sonja Entringer; Daniel S Chow; Thomas G O'Connor; Damien A Fair; Pathik D Wadhwa; Claudia Buss Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2021-03-23
Authors: Malou D Menting; Cornelieke van de Beek; Kristiina Rono; Annemieke Hoek; Henk Groen; Rebecca C Painter; Polina Girchenko; Marius Lahti-Pulkkinen; Saila B Koivusalo; Katri Räikkönen; Johan G Eriksson; Tessa J Roseboom; Kati Heinonen Journal: Scand J Psychol Date: 2019-09-09