Literature DB >> 29040604

Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome.

Varghese George1, Linda Harrison2, Margaret Roach1, Xiao-Dong Li3, Camlin Tierney2, Margaret A Fischl4, Judith Aberg5, Pablo Tebas6, David M Asmuth3, Richard B Pollard3, Catherine Godfrey7, Savita Pahwa1.   

Abstract

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  IRIS; cytokines; immune reconstitution inflammatory syndrome; microbial translocation

Mesh：

Substances：

Year:  2017        PMID： 29040604      PMCID： PMC5853564          DOI： 10.1093/infdis/jix460

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  12 in total

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10.  LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients.

Authors:  Odin Goovaerts; Wim Jennes; Marguerite Massinga-Loembé; Ann Ceulemans; William Worodria; Harriet Mayanja-Kizza; Robert Colebunders; Luc Kestens
Journal:  PLoS One       Date:  2013-11-28       Impact factor: 3.240
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Review 2.  Alcohol Use and Abuse Conspires With HIV Infection to Aggravate Intestinal Dysbiosis and Increase Microbial Translocation in People Living With HIV: A Review.

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