Marie Barba-Vasseur1,2, Nadine Bernard2,3, Sophie Pujol1,2, Paul Sagot4, Didier Riethmuller5, Gérard Thiriez6, Hélène Houot3, Jérôme Defrance7, Anne-Sophie Mariet8,9,10, Vinh-Phuc Luu1, Alice Barbier1, Eric Benzenine8, Catherine Quantin8,9,10, Frédéric Mauny1,2. 1. Centre Hospitalier Universitaire de Besançon, Centre de méthodologie clinique, 25000 Besançon, France. 2. Laboratoire Chrono-environnement UMR 6249 CNRS/Université de Bourgogne Franche-Comté, France. 3. Laboratoire ThéMA, UMR 6049 CNRS / Université Bourgogne Franche-Comté, France. 4. Centre Hospitalier Universitaire de Dijon, Service de Gynécologie-Obstétrique, 21000 Dijon, France. 5. Service de Gynécologie-Obstétrique. 6. Service de Réanimation Pédiatrique, Néonatalogie et Urgences Pédiatriques, Centre Hospitalier Universitaire de Besançon, 25000 Besançon, France. 7. Centre Scientifique et Technique du Bâtiment, Pôle Acoustique et Eclairage, 38400 Saint Martin d'Hères, France. 8. Service de biostatistique et d'informatique médicale. 9. INSERM, CIC 1432, Centre d'investigation clinique, Centre Hospitalier Universitaire de Dijon, 21000 Dijon, France. 10. INSERM UMR 1181, Biostatistique, Biomathématique, Pharmacoépidémiologie et Maladies Infectieuses (B2PHI), Université de Bourgogne Franche-Comté, 21000 Dijon, France.
Abstract
Background: Preterm birth (PB) is an important predictor of childhood morbidity and educational performance. Beyond the known risk factors, environmental factors, such as air pollution and noise, have been implicated in PB. In urban areas, these pollutants coexist. Very few studies have examined the effects of multi-exposure on the pregnancy duration. The objective of this study was to analyse the relationship between PB and environmental chronic multi-exposure to noise and air pollution in medium-sized cities. Methods: A case-control study was conducted among women living in the city of Besançon (121 671 inhabitants) or in the urban unit of Dijon (243 936 inhabitants) and who delivered in a university hospital between 2005 and 2009. Only singleton pregnancies without associated pathologies were considered. Four controls were matched to each case in terms of the mother's age and delivery location. Residential noise and nitrogen dioxide (NO2) exposures were calculated at the mother's address. Conditional logistic regression models were applied, and sensitivity analyses were performed. Results: This study included 302 cases and 1204 controls. The correlation between noise and NO2 indices ranged from 0.41 to 0.59. No significant differences were found in pollutant exposure levels between cases and controls. The adjusted odds ratios ranged between 0.96 and 1.08. Sensitivity analysis conducted using different temporal and spatial exposure windows demonstrated the same results. Conclusions: The results are in favour of a lack of connection between preterm delivery and multi-exposure to noise and air pollution in medium-sized cities for pregnant women without underlying disease.
Background: Preterm birth (PB) is an important predictor of childhood morbidity and educational performance. Beyond the known risk factors, environmental factors, such as air pollution and noise, have been implicated in PB. In urban areas, these pollutants coexist. Very few studies have examined the effects of multi-exposure on the pregnancy duration. The objective of this study was to analyse the relationship between PB and environmental chronic multi-exposure to noise and air pollution in medium-sized cities. Methods: A case-control study was conducted among women living in the city of Besançon (121 671 inhabitants) or in the urban unit of Dijon (243 936 inhabitants) and who delivered in a university hospital between 2005 and 2009. Only singleton pregnancies without associated pathologies were considered. Four controls were matched to each case in terms of the mother's age and delivery location. Residential noise and nitrogen dioxide (NO2) exposures were calculated at the mother's address. Conditional logistic regression models were applied, and sensitivity analyses were performed. Results: This study included 302 cases and 1204 controls. The correlation between noise and NO2 indices ranged from 0.41 to 0.59. No significant differences were found in pollutant exposure levels between cases and controls. The adjusted odds ratios ranged between 0.96 and 1.08. Sensitivity analysis conducted using different temporal and spatial exposure windows demonstrated the same results. Conclusions: The results are in favour of a lack of connection between preterm delivery and multi-exposure to noise and air pollution in medium-sized cities for pregnant women without underlying disease.
Authors: Corinne A Riddell; Dana E Goin; Rachel Morello-Frosch; Joshua S Apte; M Maria Glymour; Jacqueline M Torres; Joan A Casey Journal: Int J Epidemiol Date: 2021-05-31 Impact factor: 9.685