Noroyono Wibowo1, Riyan Hari Kurniawan2, Rima Irwinda1, Natasya Prameswari2. 1. a Fetomaternal Division, Department of Obstetrics and Gynecology , Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital , Jakarta , Indonesia. 2. b Department of Obstetrics and Gynecology , Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital , Jakarta , Indonesia.
Abstract
OBJECTIVE: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level. METHODS: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014. RESULTS: Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299.60 vs. 1039.50; p 0.017). Maternal cyclophilin A, vitamin D, and zinc correlation were not statistically significant (p 0.189 & p 0.853). CONCLUSION: Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D.
OBJECTIVE: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level. METHODS: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014. RESULTS: Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299.60 vs. 1039.50; p 0.017). Maternal cyclophilin A, vitamin D, and zinc correlation were not statistically significant (p 0.189 & p 0.853). CONCLUSION: Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D.
Entities:
Keywords:
CyPA; Cyclophilin A; severe preeclampsia; vitamin D; zinc
Authors: Elia Shazniza Shaaya; Azyani Yahaya; Muaatamarulain Mustangin; Nurwardah Alfian; Azimatun Noor Aizuddin; Yin Ping Wong; Geok Chin Tan Journal: Int J Environ Res Public Health Date: 2022-04-29 Impact factor: 4.614