Jari Heiskanen1,2, Anna-Maija Tolppanen2, Janne Martikainen3, Juha Hartikainen1,4, Heikki Miettinen1,4, Mikko Hippeläinen1,4, Risto P Roine2,5,6. 1. Heart Center, Kuopio University Hospital, Kuopio, Finland. 2. Research Centre for Comparative Effectiveness & Patient Safety (RECEPS), School of Pharmacy, University of Eastern Finland, Kuopio, Finland. 3. School of Pharmacy, Pharmacoeconomics & Outcomes Research Unit (PHORU), University of Eastern Finland, Kuopio, Finland. 4. School of Medicine, University of Eastern Finland, Kuopio, Finland. 5. Kuopio University Hospital, Administration, Kuopio, Finland. 6. University of Helsinki and Helsinki University Hospital, Administration, Helsinki, Finland.
Abstract
AIM: Can focusing the adverse events search to patients with poor patient-reported outcome help in targeting adverse event detection? PATIENTS & METHODS: Coronary artery revascularization patients of the Kuopio University Hospital from June 2012 to August 2014 categorized into those with clinically significant improvement (15D score change ≥0.015, n = 81) or deterioration (change ≥-0.015, n = 64) in post-intervention health-related quality of life. RESULTS: Major complications (27 vs 9%, p = 0.004) or post-intervention infections (16 vs 5%, p = 0.031) were more common among those with deteriorated score. They also tended to have more cardiovascular (19 vs 9%, p = 0.071) and minor complications (16 vs 7%, p = 0.118). CONCLUSION: Patient-reported outcomes may potentially help in targeting the adverse events search so that a larger number of adverse events can be identified for efficient learning from them.
AIM: Can focusing the adverse events search to patients with poor patient-reported outcome help in targeting adverse event detection? PATIENTS & METHODS: Coronary artery revascularization patients of the Kuopio University Hospital from June 2012 to August 2014 categorized into those with clinically significant improvement (15D score change ≥0.015, n = 81) or deterioration (change ≥-0.015, n = 64) in post-intervention health-related quality of life. RESULTS: Major complications (27 vs 9%, p = 0.004) or post-intervention infections (16 vs 5%, p = 0.031) were more common among those with deteriorated score. They also tended to have more cardiovascular (19 vs 9%, p = 0.071) and minor complications (16 vs 7%, p = 0.118). CONCLUSION:Patient-reported outcomes may potentially help in targeting the adverse events search so that a larger number of adverse events can be identified for efficient learning from them.
Authors: Jarno Kotajärvi; Anna-Maija Tolppanen; Juha Hartikainen; Heikki Miettinen; Marketta Viljakainen; Janne Martikainen; Risto P Roine; Piia Lavikainen Journal: PLoS One Date: 2022-04-01 Impact factor: 3.240