The effect of scan interval and bolus length on the quantitative accuracy of cerebral computed tomography perfusion analysis using a hollow-fiber phantom.

The shuttle scan technique is expected to extend scan range in cerebral computed tomography (CT) perfusion by 16- or 64-row multidetector CT (MDCT), but it may affect quantitative accuracy. This study aims to evaluate the effect of long scan interval and bolus length on the quantitative accuracy of perfusion indices using an innovative hollow-fiber phantom.We used an originally developed hollow-fiber hemodialyzer covered with polyurethane resin as a perfusion phantom. We scanned the phantom during various scan intervals (1-13 s) and bolus injection lengths (5, 10, 15, and 20 s), and evaluated cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time-to-peak (TTP). We verified the influence on measured values using a two-way analysis of variance (ANOVA). All measured CBF values were smaller than the theoretical CBF values, and all the measured MTT values were larger that the theoretical MTT values (95% confidence interval). Extended scan intervals resulted in more overestimation of MTT and more underestimation of CBF (p < 0.001). CBV is not affected by the change in scan interval (p < 0.001), and a longer bolus length improved the underestimation of CBV (p < 0.001). Extended scan intervals resulted in the loss of quantitative accuracy in MTT, even with longer bolus injection length, while quantitative CBF values were underestimated and TTP values overestimated. The CBV measurement was not affected by the change in scan interval, and a longer bolus injection improved the accuracy of these measurements.