Xiaoying Li1, Hongxia Song2, Zhirong Liu1, Yunsheng Bi3. 1. Three Subjects of Jinan Infectious Disease Hospital, Shandong University School of Medicine, Jinan, Shandong, People's Republic of China. 2. Ozone Treatment Center of Jinan Infectious Disease Hospital, Shandong University School of Medicine, Jinan, Shandong, People's Republic of China. 3. Department of Pharmaceutical, General Hospital of Jinan Military Region, No. 25, Shifan Road, Jinan, 250031, Shandong, People's Republic of China. biyunmed@sina.com.
Abstract
OBJECTIVES: To investigate whether miR-1260b can regulate migration and invasion of hepatocellular carcinoma (HCC) by targeting RGS22. RESULTS: miR-1260b was up-regulated in HCC tissues compared with their corresponding non-cancerous tissues. Over-expression of miR-1260b increased migration and invasion of HepG2 and SMMC-7721 cells associated with HCC. Regulator of G-protein signaling 22 (RGS22) was identified as a directly target of miR-1260b and was inhibited by miR-1260b. Knockdown of RGS22 increased proliferation of HCC cells. CONCLUSIONS: The new identified miR-1260b/RGS22 axis provides useful therapeutic methods for treatment of HCC deepening on our understanding of underlying mechanisms of HCC tumorigenesis.
OBJECTIVES: To investigate whether miR-1260b can regulate migration and invasion of hepatocellular carcinoma (HCC) by targeting RGS22. RESULTS:miR-1260b was up-regulated in HCC tissues compared with their corresponding non-cancerous tissues. Over-expression of miR-1260b increased migration and invasion of HepG2 and SMMC-7721 cells associated with HCC. Regulator of G-protein signaling 22 (RGS22) was identified as a directly target of miR-1260b and was inhibited by miR-1260b. Knockdown of RGS22 increased proliferation of HCC cells. CONCLUSIONS: The new identified miR-1260b/RGS22 axis provides useful therapeutic methods for treatment of HCC deepening on our understanding of underlying mechanisms of HCC tumorigenesis.
Entities:
Keywords:
G Protein-coupled receptors; Hepatocellular carcinoma; Invasion; MIR-1260B; Migration; RGS22