| Literature DB >> 29037944 |
Yasuko Koda1, Ko Kikuzato1, Junko Mikuni2, Akiko Tanaka2, Hitomi Yuki3, Teruki Honma3, Yuri Tomabechi2, Mutsuko Kukimoto-Niino2, Mikako Shirouzu2, Fumiyuki Shirai1, Hiroo Koyama4.
Abstract
A series of novel pyrrolo[2,3-d]pyrimidines were synthesized by introducing 15 different amino acids to 7-cyclohexyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-4-amine. Compounds with potent activities against HCK and FLT3-ITD were evaluated in viability studies with acute myeloid leukemia cell line MV4-11. Our structure activity relationship analyses lead to the identification of compound 31, which exhibited potent HCK and FLT3-ITD inhibition and activity against the MV4-11 cell line.Entities:
Keywords: Acute myeloid leukemia (AML); FMS-like tyrosine kinase 3 with internal tandem duplication mutations (FLT3-ITD); Hematopoietic cell kinase (HCK); Pyrrolo[2,3-d]pyrimidine
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Year: 2017 PMID： 29037944 DOI： 10.1016/j.bmcl.2017.10.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823