Literature DB >> 29035833

Vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats.

Seyed Esmaeil Khoshnam1, Alireza Sarkaki1, Layasadat Khorsandi2, William Winlow3, Mohammad Badavi1, Hadi Fathi Moghaddam4, Yaghoob Farbood5.   

Abstract

Cerebral hypoperfusion induced by transient bilateral common carotid arteries occlusion (tBCCAO), is associated with deleterious alterations in several physiological parameters of the animals. This study aims to investigate the effects of vanillic acid (VA) on memory impairment, locomotion and exploratory deficits, as well as histological and hippocampal long-term potentiation (LTP) injuries induced by tBCCAO procedure followed by reperfusion (BCCAO/R) in rats. Adult male Wistar rats (250-300g) were divided randomly into four groups: Sham-Operated group "Sham"; Vehicle+BCCAO/R group "BCCAO/R"; Vehicle+ Vanillic acid group "VA"; VA (100mg/kg) +BCCAO/R group "VA +BCCAO/R". Cerebral hypoperfusion was induced after 14days of pretreatment with VA and/or normal saline. To induce the animal model of hypoperfusion, bilateral common carotid arteries were occluded for 30min, followed by 72h of reperfusion. Subsequently, behavioral, histopathological and electrophysiological parameters were evaluated after BCCAO/R. Data showed that pretreatment of VA markedly improved locomotion in tBCCAO rats compared with the untreated BCCAO/R rats (p<0.05). Moreover, pretreatment of VA significantly ameliorated memory impairment in "VA+BCCAO/R" group compared with the "BCCAO/R" group (P<0.01). The field excitatory postsynaptic potential (fEPSP) amplitude and slope were significantly decreased in "BCCAO/R" group compared with Sham group (P<0.001). Data indicate that fEPSP amplitude and slope were increased in "VA+BCCAO/R" group compared with the "BCCAO/R" group (P<0.001). Furthermore, histopathological observation in VA pretreated tBCCAO rats showing markedly attenuated of cell death (P<0.01) and arrangement of CA1 neurons as compared with the untreated BCCAO/R rats. Our data confirm the protective role of VA against transient cerebral ischemia and reperfusion in rats. Moreover, it proposes that VA has a beneficial role in cerebrovascular insufficiency states.
Copyright © 2017. Published by Elsevier Masson SAS.

Entities:  

Keywords:  Electrophysiology; Hypoperfusion; Transient cerebral ischemia; Vanillic acid

Mesh：

Substances：

Year:  2017        PMID： 29035833     DOI： 10.1016/j.biopha.2017.10.052

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  8 in total

Review 1.  The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke.

Authors:  Elaheh Heydari; Masoumeh Alishahi; Farhoodeh Ghaedrahmati; William Winlow; Seyed Esmaeil Khoshnam; Amir Anbiyaiee
Journal:  Metab Brain Dis       Date:  2019-08-24       Impact factor: 3.584

2.  Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors in rats following transient bilateral common carotid occlusion and reperfusion.

Authors:  Seyed Esmaeil Khoshnam; Yaghoob Farbood; Hadi Fathi Moghaddam; Alireza Sarkaki; Mohammad Badavi; Layasadat Khorsandi
Journal:  Metab Brain Dis       Date:  2018-01-22       Impact factor: 3.584

3.  Time and Brain Region-Dependent Excitatory Neurochemical Alterations in Bilateral Common Carotid Artery Occlusion Global Ischemia Model.

Authors:  Olubukola Benedicta Ojo; Zainab Abiola Amoo; Mary Tolulope Olaleye; Sushil Kumar Jha; Afolabi Clement Akinmoladun
Journal:  Neurochem Res       Date:  2022-08-25       Impact factor: 4.414

Review 4.  Long non-coding RNAs and cell death following ischemic stroke.

Authors:  Masoumeh Alishahi; Farhoodeh Ghaedrahmati; Tannaz Akbari Kolagar; William Winlow; Negin Nikkar; Maryam Farzaneh; Seyed Esmaeil Khoshnam
Journal:  Metab Brain Dis       Date:  2019-05-04       Impact factor: 3.584

Review 5.  Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease.

Authors:  Aimee N Winter; Paula C Bickford
Journal:  Antioxidants (Basel)       Date:  2019-08-22

6.  Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice.

Authors:  Cheng-Jie Yang; Xin Li; Xiao-Qing Feng; Ye Chen; Jian-Guo Feng; Jing Jia; Ji-Cheng Wei; Jun Zhou
Journal:  Oxid Med Cell Longev       Date:  2022-08-18       Impact factor: 7.310

Review 7.  Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke.

Authors:  Meng Lu; Jindong Guo; Bowen Wu; Yuhui Zhou; Mishan Wu; Maryam Farzaneh; Seyed Esmaeil Khoshnam
Journal:  Transl Stroke Res       Date:  2020-09-25       Impact factor: 6.829

8.  Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion.

Authors:  Maria Pina Serra; Marianna Boi; Laura Poddighe; Tiziana Melis; Ylenia Lai; Gianfranca Carta; Marina Quartu
Journal:  Nutrients       Date:  2019-05-01       Impact factor: 5.717
  8 in total

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