Literature DB >> 29035776

Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.

Xin-Yi Liu1, Shan Wang1, Chuang-Jun Li1, Jie Ma1, Fang-You Chen1, Ying Peng1, Xiao-Liang Wang1, Dong-Ming Zhang2.   

Abstract

Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV, IR, ect.), HR-ESI-MS techniques and chemical methods. Screening results indicated that compounds 4, 5, 12, 13 showed moderate neuroprotective effects on H2O2-induced cellular damage in human neuroblastoma SH-SY5Y cells (10 μM).
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Araliaceae; Neuroprotective; Panax notoginseng; Saponins

Mesh：

Substances：

Year:  2017        PMID： 29035776     DOI： 10.1016/j.phytochem.2017.09.020

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  6 in total

Review 1.  Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance.

Authors:  Tanya Biswas; Upendra N Dwivedi
Journal:  Protoplasma       Date:  2019-07-11       Impact factor: 3.356

2.  New 12,23-Epoxydammarane Type Saponins Obtained from Panax notoginseng Leaves and Their Anti-Inflammatory Activity.

Authors:  Jingya Ruan; Ying Zhang; Wei Zhao; Fan Sun; Lifeng Han; Haiyang Yu; Lijie Wu; Yi Zhang; Tao Wang
Journal:  Molecules       Date:  2020-08-20       Impact factor: 4.411

3.  Effects of notoginseng leaf triterpenes on small molecule metabolism after cerebral ischemia/reperfusion injury assessed using MALDI-MS imaging.

Authors:  Lei Wang; Ting Zhu; Hui-Bo Xu; Xiao-Ping Pu; Xin Zhao; Fang Tian; Tao Ding; Gui-Bo Sun; Xiao-Bo Sun
Journal:  Ann Transl Med       Date:  2021-02

Review 4.  Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process.

Authors:  Fiqri D Khaidizar; Yasumasa Bessho; Yasukazu Nakahata
Journal:  Int J Mol Sci       Date:  2021-04-02       Impact factor: 5.923

5.  New Dammarane-Type Triterpenoid Saponins from Panax notoginseng Leaves and Their Nitric Oxide Inhibitory Activities.

Authors:  Fan Sun; Jingya Ruan; Wei Zhao; Ying Zhang; Guilin Xiang; Jiejing Yan; Mimi Hao; Lijie Wu; Yi Zhang; Tao Wang
Journal:  Molecules       Date:  2019-12-29       Impact factor: 4.411

6.  HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways.

Authors:  Weijie Xie; Ting Zhu; Xi Dong; Fengwei Nan; Xiangbao Meng; Ping Zhou; Guibo Sun; Xiaobo Sun
Journal:  Biomolecules       Date:  2019-09-20
  6 in total

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