Brian S Mohlenhoff1,2,3, Aoife O'Donovan4,5, Michael W Weiner4,6,7, Thomas C Neylan4,6. 1. Departments of Psychiatry, University of California, San Francisco, CA, USA. Brian.Mohlenhoff@ucsf.edu. 2. Center for Imaging of Neurodegenerative Disease, Veterans Administration Medical Center, 4150 Clement Street (116P), San Francisco, CA, 94121, USA. Brian.Mohlenhoff@ucsf.edu. 3. Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA. Brian.Mohlenhoff@ucsf.edu. 4. Departments of Psychiatry, University of California, San Francisco, CA, USA. 5. Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA. 6. Center for Imaging of Neurodegenerative Disease, Veterans Administration Medical Center, 4150 Clement Street (116P), San Francisco, CA, 94121, USA. 7. Departments of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Abstract
PURPOSE OF REVIEW: Posttraumatic stress disorder (PTSD) is associated with increased risk for dementia, yet mechanisms are poorly understood. RECENT FINDINGS: Recent literature suggests several potential mechanisms by which sleep impairments might contribute to the increased risk of dementia observed in PTSD. First, molecular, animal, and imaging studies indicate that sleep problems lead to cellular damage in brain structures crucial to learning and memory. Second, recent studies have shown that lack of sleep might precipitate the accumulation of harmful amyloid proteins. Finally, sleep and PTSD are associated with elevated inflammation, which, in turn, is associated with dementia, possibly via cytokine-mediated neural toxicity and reduced neurogenesis. A better understanding of these mechanisms may yield novel treatment approaches to reduce neurodegeneration in PTSD. The authors emphasize the importance of including sleep data in studies of PTSD and cognition and identify next steps.
PURPOSE OF REVIEW: Posttraumatic stress disorder (PTSD) is associated with increased risk for dementia, yet mechanisms are poorly understood. RECENT FINDINGS: Recent literature suggests several potential mechanisms by which sleep impairments might contribute to the increased risk of dementia observed in PTSD. First, molecular, animal, and imaging studies indicate that sleep problems lead to cellular damage in brain structures crucial to learning and memory. Second, recent studies have shown that lack of sleep might precipitate the accumulation of harmful amyloid proteins. Finally, sleep and PTSD are associated with elevated inflammation, which, in turn, is associated with dementia, possibly via cytokine-mediated neural toxicity and reduced neurogenesis. A better understanding of these mechanisms may yield novel treatment approaches to reduce neurodegeneration in PTSD. The authors emphasize the importance of including sleep data in studies of PTSD and cognition and identify next steps.
Authors: Ilana S Hairston; Milton T M Little; Michael D Scanlon; Monique T Barakat; Theo D Palmer; Robert M Sapolsky; H Craig Heller Journal: J Neurophysiol Date: 2005-07-13 Impact factor: 2.714
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Authors: T C Neylan; C R Marmar; T J Metzler; D S Weiss; D F Zatzick; K L Delucchi; R M Wu; F B Schoenfeld Journal: Am J Psychiatry Date: 1998-07 Impact factor: 18.112
Authors: Brian S Mohlenhoff; Philip S Insel; R Scott Mackin; Thomas C Neylan; Derek Flenniken; Rachel Nosheny; Anne Richards; Paul Maruff; Michael W Weiner Journal: J Clin Sleep Med Date: 2018-09-15 Impact factor: 4.062
Authors: Kerry J Ressler; Sabina Berretta; Vadim Y Bolshakov; Isabelle M Rosso; Edward G Meloni; Scott L Rauch; William A Carlezon Journal: Nat Rev Neurol Date: 2022-03-29 Impact factor: 44.711