Q Zhou1, M Zhong1, S Yao2,3, X Jin2, Y Liu2, C Tan4, X Zhu2,3, J Yi2,3. 1. Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, Guangdong, China. 2. Medical Psychological Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 3. Medical Psychological Institute, Central South University, Changsha, Hunan, China. 4. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Abstract
OBJECTIVE: Although the frontolimbic cortex has been implicated in borderline personality disorder (BPD), information about possible asymmetries in this region in patients with BPD is limited. This study aimed to examine whether frontolimbic cortex asymmetries differ between patients with BPD and healthy individuals. METHODS: The brains of 30 young adult patients with BPD and 32 healthy control subjects were scanned with magnetic resonance imaging (MRI). The participants completed self-report scales assessing impulsivity, affect intensity and other psychological variables. Gray matter volume, surface area, and cortical thickness in regions of interest (ROIs), namely anterior insula (AI) and anterior cingulate cortex (ACC) were determined and the data were probed for hemisphere-group interactions. RESULTS: Relative to controls, patients with BPD had reduced cortical thickness in left ACC and less surface area and gray matter volume in left AI. Significant group-hemisphere interactions were observed for gray matter volume and surface area of AI and for cortical thickness of ACC. Post hoc analysis showed that the BPD patients had greater frontolimbic cortex asymmetry than healthy controls; furthermore, greater asymmetry of AI&ACC correlated with a higher score in attention subscale of Barratt Impulsiveness Scale. CONCLUSION: Patients with BPD have greater frontolimbic asymmetry than healthy individuals.
OBJECTIVE: Although the frontolimbic cortex has been implicated in borderline personality disorder (BPD), information about possible asymmetries in this region in patients with BPD is limited. This study aimed to examine whether frontolimbic cortex asymmetries differ between patients with BPD and healthy individuals. METHODS: The brains of 30 young adult patients with BPD and 32 healthy control subjects were scanned with magnetic resonance imaging (MRI). The participants completed self-report scales assessing impulsivity, affect intensity and other psychological variables. Gray matter volume, surface area, and cortical thickness in regions of interest (ROIs), namely anterior insula (AI) and anterior cingulate cortex (ACC) were determined and the data were probed for hemisphere-group interactions. RESULTS: Relative to controls, patients with BPD had reduced cortical thickness in left ACC and less surface area and gray matter volume in left AI. Significant group-hemisphere interactions were observed for gray matter volume and surface area of AI and for cortical thickness of ACC. Post hoc analysis showed that the BPD patients had greater frontolimbic cortex asymmetry than healthy controls; furthermore, greater asymmetry of AI&ACC correlated with a higher score in attention subscale of Barratt Impulsiveness Scale. CONCLUSION:Patients with BPD have greater frontolimbic asymmetry than healthy individuals.
Authors: Hyuna Kim; Ja-Hye Ahn; Joo Young Lee; Yong Hun Jang; Young-Eun Kim; Johanna Inhyang Kim; Bung-Nyun Kim; Hyun Ju Lee Journal: J Clin Med Date: 2022-05-31 Impact factor: 4.964
Authors: Joo Young Lee; Yong-Ho Choi; Jong Ho Cha; Ji Young Lee; Young-Jun Lee; Bo-Hyun Kim; Il-Kewon Kim; Jong-Min Lee; Hyun Ju Lee Journal: Sci Rep Date: 2021-01-14 Impact factor: 4.379