| Literature DB >> 29034887 |
Yanli Liu1, Feima Wu1, Yuanqi Zhuang1, Dongsheng Guo1, Nasir Abbas1, Ruzi Wei1, Kepin Wang2, Yan Chen3, Jiawang Tao1, Yuhang Wu3, Fang Yuan3, Tingcai Pan1, Fan Yang3, Keyu Lai2, Liangxue Lai4, Yin-Xiong Li5.
Abstract
miR-122 is the most abundant miRNA in the human liver, accounting for 52% of the entire hepatic miRNome. Previous studies have demonstrated that miR-122 plays key roles in hepatocyte growth, metabolism, and homeostasis. Here, we created three miR-122 knockout human embryonic stem cell line lines, WAe001-A-7, WAe001-A-8, and WAe001-A-9, using the CRISPR/Cas9 technique. These mutated cell lines retained their pluripotency, in vitro differentiation potential, normal morphology, and karyotype.Entities:
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Year: 2017 PMID： 29034887 DOI： 10.1016/j.scr.2017.06.004
Source DB: PubMed Journal: Stem Cell Res ISSN： 1873-5061 Impact factor: 2.020