Giuseppe M C Rosano 1,2 , Ilaria Spoletini 2 , Walter Gianni 3 , Cristiana Vitale 1,2 Show Affiliations »
Abstract
BACKGROUND: Prevention of stroke is a pivotal intervention in the management of patients with atrial fibrillation (AF). Because of the difficulties of safely implementing Vitamin K Antagonists in all patients, there has been a growing interest in improving the pharmacological management of AF with newer antithrombotic agents. The new oral anticoagulants (NOACs) have been developed to overcome the limitations and improve the efficacy of the conventional oral anticoagulant drugs. Among the NOACs, apixaban - a very specific antagonist of activated factor Xa - has pharmacokinetic and pharmacodynamic properties that allow significant efficacy in AF management. OBJECTIVE: The aim of this review is to summarise the available data on the efficacy of apixaban in patients with AF, with a particular focus on the implications for its clinical management. RESULTS AND CONCLUSION: Clinical application of apixaban in subgroups of patients with AF is still under investigation and some contraindications should be taken into account. Despite these limitations, apixaban is an effective alternative to warfarin and aspirin for stroke prevention in AF, with encouraging evidence also in terms of adherence to treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Prevention of stroke is a pivotal intervention in the management of patients with atrial fibrillation (AF ). Because of the difficulties of safely implementing Vitamin K Antagonists in all patients , there has been a growing interest in improving the pharmacological management of AF with newer antithrombotic agents. The new oral anticoagulants (NOACs ) have been developed to overcome the limitations and improve the efficacy of the conventional oral anticoagulant drugs. Among the NOACs , apixaban - a very specific antagonist of activated factor Xa - has pharmacokinetic and pharmacodynamic properties that allow significant efficacy in AF management. OBJECTIVE: The aim of this review is to summarise the available data on the efficacy of apixaban in patients with AF , with a particular focus on the implications for its clinical management. RESULTS AND CONCLUSION: Clinical application of apixaban in subgroups of patients with AF is still under investigation and some contraindications should be taken into account. Despite these limitations, apixaban is an effective alternative to warfarin and aspirin for stroke prevention in AF , with encouraging evidence also in terms of adherence to treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Gene
Species
Keywords:
Apixaban; Vitamin K antagonists; atrial fibrillation; major bleeding; new oral anticoagulants; stroke.
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Year: 2018
PMID： 29034832 DOI： 10.2174/1389450118666171013095413
Source DB: PubMed Journal: Curr Drug Targets ISSN： 1389-4501 Impact factor: 3.465