Literature DB >> 29034739

Regression of an intramedullary spinal cord metastasis with a checkpoint inhibitor: a case report.

Kester A Phillips1, Elizabeth Gaughan2, Alejandro Gru3, David Schiff1.   

Abstract

Intramedullary spinal cord metastasis is an increasingly common diagnosis in patients with cancer largely owing to new imaging techniques and the increase lifespan of patients with malignant tumors. The diagnosis confers significant morbidity and a poor prognosis. Mainstay palliative treatment options include corticosteroids, fractionated radiotherapy and surgery in select cases. In the modern era of immunotherapy for the treatment of several tumor types, the efficacy of these agents against parenchymal CNS tumors remains unanswered. Here, we report a case of regression of an intramedullary spinal cord metastasis with a checkpoint inhibitor.

Entities:  

Keywords:  anti-programmed cell death-1; checkpoint inhibitors; intramedullary spinal cord metastasis; nivolumab; pembrolizumab

Mesh:

Substances:

Year:  2017        PMID: 29034739      PMCID: PMC6004890          DOI: 10.2217/cns-2017-0007

Source DB:  PubMed          Journal:  CNS Oncol        ISSN: 2045-0907


  17 in total

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  5 in total

1.  Long-Lasting Response to Nivolumab for a Patient With Lynch Syndrome-Associated Lung Adenocarcinoma.

Authors:  Keita Masuzawa; Takanori Asakura; Shinnosuke Ikemura; Hiroyuki Yasuda; Ichiro Kawada; Sosuke Takaoka; Yuichiro Hayashi; Takeshi Nakajima; Masami Arai; Koichi Fukunaga; Kenzo Soejima
Journal:  JCO Precis Oncol       Date:  2020-02-14

2.  Intramedullary spinal cord metastasis in malignancies: an institutional analysis and review.

Authors:  Jincai Lv; Bailong Liu; Xiaoyue Quan; Cheng Li; Lihua Dong; Min Liu
Journal:  Onco Targets Ther       Date:  2019-06-21       Impact factor: 4.147

3.  Image-Guided Robotic Radiosurgery for the Management of Intramedullary Spinal Cord Metastases-A Multicenter Experience.

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Journal:  Cancers (Basel)       Date:  2021-01-15       Impact factor: 6.639

4.  Glioma Immunotherapy: Advances and Challenges for Spinal Cord Gliomas.

Authors:  Clare Grady; Kaitlyn Melnick; Ken Porche; Farhad Dastmalchi; Daniel J Hoh; Maryam Rahman; Ashley Ghiaseddin
Journal:  Neurospine       Date:  2022-02-02

5.  Clinical Features, Treatments, and Prognosis of Intramedullary Spinal Cord Metastases From Lung Cancer: A Case Series and Systematic Review.

Authors:  Liang Wu; Li'ao Wang; Jun Yang; Wenqing Jia; Yulun Xu
Journal:  Neurospine       Date:  2022-02-03
  5 in total

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