Literature DB >> 2903471

Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro.

R S Neuman1, Y Ben-Ari, M Gho, E Cherubini.   

Abstract

Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 microM) reversibly blocked the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow gamma-aminobutyric acid (GABA)-mediated inhibition. Membrane potential, input resistance and spike accommodation were not altered. Inward currents induced by quisqualate were reduced to a greater extent by CNQX than those induced by kainate or N-methyl-D-aspartate. We suggest that CNQX may be a useful antagonist to study excitatory amino acid-mediated synaptic transmission.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2903471     DOI： 10.1016/0304-3940(88)90743-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  Unique properties of NMDA receptors enhance synaptic excitation of radiatum giant cells in rat hippocampus.

Authors:  E D Kirson; Y Yaari
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

2.  Giant synaptic potentials in immature rat CA3 hippocampal neurones.

Authors:  Y Ben-Ari; E Cherubini; R Corradetti; J L Gaiarsa
Journal:  J Physiol       Date:  1989-09       Impact factor: 5.182

3.  Effects of new non-N-methyl-D-aspartate antagonists on synaptic transmission in the in vitro rat hippocampus.

Authors:  M Andreasen; J D Lambert; M S Jensen
Journal:  J Physiol       Date:  1989-07       Impact factor: 5.182

4.  Noradrenaline receptors participate in the regulation of GABAergic inhibition in area CA1 of the rat hippocampus.

Authors:  M Andreasen; J D Lambert
Journal:  J Physiol       Date:  1991-08       Impact factor: 5.182

5.  The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors.

Authors:  G G Hwa; M Avoli
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

6.  Persistent pulsatile release of glutamate induced by N-methyl-D-aspartate in neonatal rat hippocampal neurones.

Authors:  E Cherubini; Y Ben-Ari; S Ito; K Krnjević
Journal:  J Physiol       Date:  1991-05       Impact factor: 5.182

7.  6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus.

Authors:  J F Blake; R G Yates; M W Brown; G L Collingridge
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

8.  Characterization of metabotropic glutamate receptor-mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurones.

Authors:  S Rahman; R S Neuman
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

9.  Blockade of synaptic transmission from hair cells to auditory afferent nerves by 6-cyano-2,3-dihydroxy-7-nitroquinoxaline, a selective non-NMDA receptor antagonist.

Authors:  K Doi; N Mori; T Matsunaga; T Tsumoto
Journal:  Eur Arch Otorhinolaryngol       Date:  1990       Impact factor: 2.503

Review 10.  Information processing and synaptic plasticity at hippocampal mossy fiber terminals.

Authors:  Alesya Evstratova; Katalin Tóth
Journal:  Front Cell Neurosci       Date:  2014-02-04       Impact factor: 5.505
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.