Literature DB >> 29032755

Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications.

Muhammad A Abdul-Ghani1,2, Amin Jayyousi3, Ralph A DeFronzo1, Nidal Asaad3, Jassim Al-Suwaidi3.   

Abstract

Insulin resistance (IR) is a cardinal feature of type 2 diabetes mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known cardiovascular disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  HDL; Insulin resistance; LDL; cardiovascular disease; insulin sensitizers; type 2 diabetes.

Mesh：

Substances：

Year:  2019        PMID： 29032755     DOI： 10.2174/1570161115666171010115119

Source DB:  PubMed          Journal:  Curr Vasc Pharmacol        ISSN： 1570-1611            Impact factor:   2.719


  17 in total

1.  Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking.

Authors:  Lauren K Park; Elizabeth J Parks; Ryan J Pettit-Mee; Makenzie L Woodford; Thaysa Ghiarone; James A Smith; Allan R K Sales; Luis A Martinez-Lemus; Camila Manrique-Acevedo; Jaume Padilla
Journal:  J Appl Physiol (1985)       Date:  2020-07-02

2.  Pioglitazone and cardiovascular risk in T2DM patients: is it good for all?

Authors:  Muhammad Abdul-Ghani; Amin Jayyous; Nidal Asaad; Sherif Helmy; Jassim Al-Suwaidi
Journal:  Ann Transl Med       Date:  2018-05

Review 3.  Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system.

Authors:  Kun Zhao; Chuan-Xi Yang; Peng Li; Wei Sun; Xiang-Qing Kong
Journal:  J Zhejiang Univ Sci B       Date:  2020-07       Impact factor: 3.066

4.  Chitosan-Encapsulated Nano-selenium Targeting TCF7L2, PPARγ, and CAPN10 Genes in Diabetic Rats.

Authors:  Omayma A R Abozaid; Sawsan M El-Sonbaty; Neama M A Hamam; Moustafa A Farrag; Ahmad S Kodous
Journal:  Biol Trace Elem Res       Date:  2022-03-02       Impact factor: 3.738

5.  Correlation between salivary HBD-2 and LL-37 expression levels with blood glucose and periodontal status in patients with type 2 diabetes mellitus.

Authors:  Zunsheng Xiao; Wencui Ding; Chao Wen; Chao Ge; Lu Liu; Ke Xu; Sumin Cao
Journal:  Am J Transl Res       Date:  2022-05-15       Impact factor: 3.940

6.  Ellagic acid regulates hyperglycemic state through modulation of pancreatic IL-6 and TNF- α immunoexpression.

Authors:  Manal M Elbandrawy; Osama Sweef; Doaa Elgamal; Tarek M Mohamed; Rehab M Elgharabawy
Journal:  Saudi J Biol Sci       Date:  2022-03-10       Impact factor: 4.052

7.  Prevalence of cardiovascular diseases and associated factors among adults from southwest Iran: Baseline data from Hoveyzeh Cohort Study.

Authors:  Nader Saki; Majid Karandish; Bahman Cheraghian; Habib Heybar; Seyed Jalal Hashemi; Maryam Azhdari
Journal:  BMC Cardiovasc Disord       Date:  2022-07-08       Impact factor: 2.174

8.  Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults.

Authors:  Han-Bin Huang; Po-Keng Cheng; Chi-Ying Siao; Yuan-Ting C Lo; Wei-Chun Chou; Po-Chin Huang
Journal:  Environ Health       Date:  2022-07-01       Impact factor: 7.123

9.  The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism.

Authors:  Carlos Henríquez-Olguín; Susanna Boronat; Claudio Cabello-Verrugio; Enrique Jaimovich; Elena Hidalgo; Thomas E Jensen
Journal:  Antioxid Redox Signal       Date:  2019-11-01       Impact factor: 8.401

Review 10.  Diabetic Cardiomyopathy: Impact of Biological Sex on Disease Development and Molecular Signatures.

Authors:  Ryan Toedebusch; Anthony Belenchia; Lakshmi Pulakat
Journal:  Front Physiol       Date:  2018-05-03       Impact factor: 4.566
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