Literature DB >> 29032536

Characterization of Borrelia burgdorferi Binding to Mammalian Cells and Extracellular Matrix.

Yi-Pin Lin1, John M Leong2.   

Abstract

Lyme disease Borreliae produces outer surface adhesins to confer bacterial attachment to the extracellular matrix (ECM) components on the surface of mammalian cells. Here, we describe protocols to characterize the activity and specificity of these adhesins by flow cytometry or measurement of the binding of radiolabeled spirochetes to immobilized ECM or mammalian cells.

Entities:  

Keywords:  Adhesins; Borrelia burgdorferi; Extracellular matrix; Flow cytometry; Lyme disease; Mammalian cells; Radiolabeling

Mesh：

Substances：

Year:  2018        PMID： 29032536      PMCID： PMC6291642          DOI： 10.1007/978-1-4939-7383-5_5

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  25 in total

1.  Characterization of a candidate Borrelia burgdorferi beta3-chain integrin ligand identified using a phage display library.

Authors:  J Coburn; W Chege; L Magoun; S C Bodary; J M Leong
Journal:  Mol Microbiol       Date:  1999-12       Impact factor: 3.501

2.  Decorin-binding adhesins from Borrelia burgdorferi.

Authors:  B P Guo; E L Brown; D W Dorward; L C Rosenberg; M Höök
Journal:  Mol Microbiol       Date:  1998-11       Impact factor: 3.501

Review 3.  Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes.

Authors:  Justin D Radolf; Melissa J Caimano; Brian Stevenson; Linden T Hu
Journal:  Nat Rev Microbiol       Date:  2012-01-09       Impact factor: 60.633

Review 4.  The role of Borrelia burgdorferi outer surface proteins.

Authors:  Melisha R Kenedy; Tiffany R Lenhart; Darrin R Akins
Journal:  FEMS Immunol Med Microbiol       Date:  2012-05-21

Review 5.  Illuminating the roles of the Borrelia burgdorferi adhesins.

Authors:  Jenifer Coburn; John Leong; George Chaconas
Journal:  Trends Microbiol       Date:  2013-07-19       Impact factor: 17.079

6.  Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

Authors:  J Seshu; M Dolores Esteve-Gassent; Maria Labandeira-Rey; Jung Hwa Kim; Jerome P Trzeciakowski; Magnus Höök; Jonathan T Skare
Journal:  Mol Microbiol       Date:  2006-03       Impact factor: 3.501

7.  Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection.

Authors:  Xiuli Yang; Yi-Pin Lin; Ryan D Heselpoth; Ozlem Buyuktanir; Jinhong Qin; Faith Kung; Daniel C Nelson; John M Leong; Utpal Pal
Journal:  Cell Microbiol       Date:  2015-08-31       Impact factor: 3.715

8.  A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity.

Authors:  Xiuli Yang; Adam S Coleman; Juan Anguita; Utpal Pal
Journal:  PLoS Pathog       Date:  2009-03-06       Impact factor: 6.823

9.  BB0347, from the lyme disease spirochete Borrelia burgdorferi, is surface exposed and interacts with the CS1 heparin-binding domain of human fibronectin.

Authors:  Robert A Gaultney; Tammy Gonzalez; Angela M Floden; Catherine A Brissette
Journal:  PLoS One       Date:  2013-09-27       Impact factor: 3.240

10.  Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete.

Authors:  Yi-Pin Lin; Vivian Benoit; Xiuli Yang; Raúl Martínez-Herranz; Utpal Pal; John M Leong
Journal:  PLoS Pathog       Date:  2014-07-31       Impact factor: 6.823
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