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Literature DB >> 29032501

Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-α protein stability and activity.

Abstract

The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: ATP-dependent chromatin remodeler; Chromatin reprogramming; Epigenetic eraser; Epigenetic reader; Epigenetic writer; Gene regulation; Hypoxia-inducible factor

Mesh：

Substances：

Year: 2017 PMID： 29032501 PMCID： PMC5984203 DOI： 10.1007/s00018-017-2684-9

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

107 in total

1. FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.

Authors: Uk-Il Ju; Jong-Wan Park; Hyoung-Sook Park; Sang Jeong Kim; Yang-Sook Chun
Journal: Biochem Biophys Res Commun Date: 2015-07-14 Impact factor: 3.575

2. Functional regulation of hypoxia inducible factor-1α by SET9 lysine methyltransferase.

Authors: Qiong Liu; Hao Geng; Changhui Xue; Tomasz M Beer; David Z Qian
Journal: Biochim Biophys Acta Date: 2015-01-28

3. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors: P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal: Nature Date: 1999-05-20 Impact factor: 49.962

4. An essential role for p300/CBP in the cellular response to hypoxia.

Authors: Z Arany; L E Huang; R Eckner; S Bhattacharya; C Jiang; M A Goldberg; H F Bunn; D M Livingston
Journal: Proc Natl Acad Sci U S A Date: 1996-11-12 Impact factor: 11.205

5. The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.

Authors: Frédéric Dayan; Danièle Roux; M Christiane Brahimi-Horn; Jacques Pouyssegur; Nathalie M Mazure
Journal: Cancer Res Date: 2006-04-01 Impact factor: 12.701

6. The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells.

Authors: Su-Yan Dong; Yan-Jie Guo; Ya Feng; Xin-Xin Cui; Sheng-Han Kuo; Te Liu; Yun-Cheng Wu
Journal: Biochem Biophys Res Commun Date: 2016-01-06 Impact factor: 3.575

Review 7. Pontin and reptin, two related ATPases with multiple roles in cancer.

Authors: Otmar Huber; Ludovic Ménard; Valérie Haurie; Alexandra Nicou; Danièle Taras; Jean Rosenbaum
Journal: Cancer Res Date: 2008-09-01 Impact factor: 12.701

8. The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH.

Authors: Andrew Melvin; Sharon Mudie; Sonia Rocha
Journal: Mol Biol Cell Date: 2011-09-07 Impact factor: 4.138

9. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.

Authors: G L Semenza; B H Jiang; S W Leung; R Passantino; J P Concordet; P Maire; A Giallongo
Journal: J Biol Chem Date: 1996-12-20 Impact factor: 5.157

10. Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.

Authors: Yadi Huang; Joshua Kapere Ochieng; Marjon Buscop-van Kempen; Anne Boerema-de Munck; Sigrid Swagemakers; Wilfred van Ijcken; Frank Grosveld; Dick Tibboel; Robbert J Rottier
Journal: PLoS One Date: 2013-02-25 Impact factor: 3.240

25 in total

1. ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.

Authors: Yan Chen; Bo Zhang; Lei Bao; Lai Jin; Mingming Yang; Yan Peng; Ashwani Kumar; Jennifer E Wang; Chenliang Wang; Xuan Zou; Chao Xing; Yingfei Wang; Weibo Luo
Journal: J Clin Invest Date: 2018-04-09 Impact factor: 14.808

2. Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome.

Authors: Giovanni A Carosso; Leandros Boukas; Jonathan J Augustin; Ha Nam Nguyen; Briana L Winer; Gabrielle H Cannon; Johanna D Robertson; Li Zhang; Kasper D Hansen; Loyal A Goff; Hans T Bjornsson
Journal: JCI Insight Date: 2019-10-17

Review 3. The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies.

Authors: Joaquín Araos; Jonathan P Sleeman; Boyan K Garvalov
Journal: Clin Exp Metastasis Date: 2018-08-31 Impact factor: 5.150

4. Protein arginine N-methyltransferase 1 gene polymorphism is associated with proliferative diabetic retinopathy in a Japanese population.

Authors: Hiroaki Iwasaki; Masayoshi Shichiri
Journal: Acta Diabetol Date: 2021-10-14 Impact factor: 4.280