C Zhong1, W Yang2, Y Li2, L Zou2, Z Deng2, M Liu2, X Huang2. 1. Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, Dieshan district, Wuzhou, 543002, China. zhongcan2016@163.com. 2. Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, Dieshan district, Wuzhou, 543002, China.
Abstract
PURPOSE: The efficacy and safety of sublingual immunotherapy (SLIT) in house dust mite-induced allergic asthma (AA) have yet to be firmly established, especially in adult patients. Our objective is to evaluate the efficacy of SLIT with Dermatophagoides farinae drops in adult patients with AA. METHODS:One hundred and thirty-four adult patient data with house dust mite (HDM)-induced AA who had been treated for 2 years were collected. These patient data that we collected were divided into the SLIT group (n = 85) and control group (n = 49). All patients were treated with low to moderate dose of inhaled glucocorticoid and long-acting β2 agonists. Patients in the SLIT group were further treated with D. farinae drops. Clinical scores including the total asthma symptom score (TASS), total asthma medicine score (TAMS), asthma control test (ACT), and peak flow percentage (PEF%) were assessed before treatment and at yearly visits. The presence of adverse events (AEs) were recorded once a month. RESULTS: Before treatment, the PEF% in the SLIT group was significantly lower than that in the control group (p < 0.05). After 2 years, both treatments were effective in the clinical scores when compared with baseline values (all p < 0.001). Meanwhile, the SLIT group showed significantly lower TASS and TAMS (all p < 0.001) and higher ACT (p < 0.001) and PEF% (p < 0.05) when compared with the control group. No severe systemic AEs were reported. CONCLUSIONS:SLIT with D. farinae drops plus pharmacotherapy is more effective than routine drug treatment in adult patients with AA.
RCT Entities:
PURPOSE: The efficacy and safety of sublingual immunotherapy (SLIT) in house dust mite-induced allergic asthma (AA) have yet to be firmly established, especially in adult patients. Our objective is to evaluate the efficacy of SLIT with Dermatophagoides farinae drops in adult patients with AA. METHODS: One hundred and thirty-four adult patient data with house dust mite (HDM)-induced AA who had been treated for 2 years were collected. These patient data that we collected were divided into the SLIT group (n = 85) and control group (n = 49). All patients were treated with low to moderate dose of inhaled glucocorticoid and long-acting β2 agonists. Patients in the SLIT group were further treated with D. farinae drops. Clinical scores including the total asthma symptom score (TASS), total asthma medicine score (TAMS), asthma control test (ACT), and peak flow percentage (PEF%) were assessed before treatment and at yearly visits. The presence of adverse events (AEs) were recorded once a month. RESULTS: Before treatment, the PEF% in the SLIT group was significantly lower than that in the control group (p < 0.05). After 2 years, both treatments were effective in the clinical scores when compared with baseline values (all p < 0.001). Meanwhile, the SLIT group showed significantly lower TASS and TAMS (all p < 0.001) and higher ACT (p < 0.001) and PEF% (p < 0.05) when compared with the control group. No severe systemic AEs were reported. CONCLUSIONS: SLIT with D. farinae drops plus pharmacotherapy is more effective than routine drug treatment in adult patients with AA.
Authors: Wayne R Thomas; Wendy-Anne Smith; Belinda J Hales; Kristina L Mills; Richard M O'Brien Journal: Int Arch Allergy Immunol Date: 2002-09 Impact factor: 2.749
Authors: Antonio Basomba; Ana I Tabar; Dolores Hernández F de Rojas; Blanca E García; Remedios Alamar; José M Olaguíbel; Jaime Moscoso del Prado; Santiago Martín; Pilar Rico Journal: J Allergy Clin Immunol Date: 2002-06 Impact factor: 10.793
Authors: G Walter Canonica; Jean Bousquet; Thomas Casale; Richard F Lockey; Carlos E Baena-Cagnani; Ruby Pawankar; Paul C Potter; Philippe J Bousquet; Linda S Cox; Stephen R Durham; Harold S Nelson; Giovanni Passalacqua; Dermot P Ryan; Jan L Brozek; Enrico Compalati; Ronald Dahl; Luis Delgado; Roy Gerth van Wijk; Richard G Gower; Dennis K Ledford; Nelson Rosario Filho; Erkka J Valovirta; Osman M Yusuf; Torsten Zuberbier; Wahiduzzaman Akhanda; Raul Castro Almarales; Ignacio Ansotegui; Floriano Bonifazi; Jan Ceuppens; Tomás Chivato; Darina Dimova; Diana Dumitrascu; Luigi Fontana; Constance H Katelaris; Ranbir Kaulsay; Piotr Kuna; Dèsirée Larenas-Linnemann; Manolis Manoussakis; Kristof Nekam; Carlos Nunes; Robyn O'Hehir; José M Olaguibel; Nerin Bahceciler Onder; Jung Won Park; Alfred Priftanji; Robert Puy; Luis Sarmiento; Glenis Scadding; Peter Schmid-Grendelmeier; Ester Seberova; Revaz Sepiashvili; Dirceu Solé; Alkis Togias; Carlo Tomino; Elina Toskala; Hugo Van Beever; Stefan Vieths Journal: Allergy Date: 2009-12 Impact factor: 13.146
Authors: Angel Moral; Victoria Moreno; Francisco Girón; David El-Qutob; José D Moure; Manuel Alcántara; Antonia Padial; Alberto G Oehling; Carmen Millán; Fernando de la Torre Journal: J Asthma Allergy Date: 2016-06-29