Literature DB >> 29032368

The ethical justification for the use of non-human primates in research: the Weatherall report revisited.

Gardar Arnason.   

Abstract

The Weatherall report on the use of non-human primates in research was published in 2006. Its main conclusion was that there is a strong scientific case for the use of non-human primates in some cases, but the report stressed the importance of evaluating each case in the light of the availability of alternatives. In addition to arguing for the scientific necessity of using non-human primates in research, the report also provided an ethical justification. As could be expected, the report was harshly criticised by animal rights groups, but in the academic literature, only two critical replies appeared. In what follows, I will describe the ethical justification for non-human primate research as it is laid out in the Weatherall report and then consider the criticism in the academic literature. I conclude that the report's ethical justification for the use of non-human primates in research, in particular in basic neuroscientific research, has not been convincingly challenged by its critics. Since the criticism of the report is limited and represents only a small part of the academic discussion about the use of non-human primates in research, and a still smaller part of the ethical discussion about animal research, it is important that the discussion continue both at the academic and social level. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  animal experimentation; quality/value of life/personhood; research ethics

Mesh:

Year:  2017        PMID: 29032368     DOI: 10.1136/medethics-2016-103827

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  9 in total

1.  Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.

Authors:  Ines Frank; Mariasole Cigoli; Muhammad S Arif; Marissa D Fahlberg; Stephanie Maldonado; Giulia Calenda; Amarendra Pegu; Eun Sung Yang; Reda Rawi; Gwo-Yu Chuang; Hui Geng; Cuiping Liu; Tongqing Zhou; Peter D Kwong; James Arthos; Claudia Cicala; Brooke F Grasperge; James L Blanchard; Agegnehu Gettie; Christine M Fennessey; Brandon F Keele; Monica Vaccari; Thomas J Hope; Anthony S Fauci; John R Mascola; Elena Martinelli
Journal:  Sci Transl Med       Date:  2021-08-18       Impact factor: 19.319

2.  Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrol supplementation in a primate.

Authors:  Alexandre Dal-Pan; Fabien Pifferi; Julia Marchal; Jean-Luc Picq; Fabienne Aujard
Journal:  PLoS One       Date:  2011-01-31       Impact factor: 3.240

3.  Of Men and Mice: Modeling the Fragile X Syndrome.

Authors:  Regina Dahlhaus
Journal:  Front Mol Neurosci       Date:  2018-03-15       Impact factor: 5.639

4.  Attitudes toward animals, and how species and purpose affect animal research justifiability, among undergraduate students and faculty.

Authors:  Eric P Sandgren; Robert Streiffer; Jennifer Dykema; Nadia Assad; Jackson Moberg
Journal:  PLoS One       Date:  2020-05-29       Impact factor: 3.240

5.  Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Authors:  Joseph C Mudd; Kathleen Busman-Sahay; Sarah R DiNapoli; Stephen Lai; Virginia Sheik; Andrea Lisco; Claire Deleage; Brian Richardson; David J Palesch; Mirko Paiardini; Mark Cameron; Irini Sereti; R Keith Reeves; Jacob D Estes; Jason M Brenchley
Journal:  Nat Commun       Date:  2018-09-27       Impact factor: 14.919

Review 6.  The Emergence and Development of Animal Research Ethics: A Review with a Focus on Nonhuman Primates.

Authors:  Gardar Arnason
Journal:  Sci Eng Ethics       Date:  2020-04-29       Impact factor: 3.525

7.  Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur.

Authors:  Anisur Rahman; Solène Languille; Yves Lamberty; Claudio Babiloni; Martine Perret; Regis Bordet; Olivier J Blin; Tom Jacob; Alexandra Auffret; Esther Schenker; Jill Richardson; Fabien Pifferi; Fabienne Aujard
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240

Review 8.  Nonhuman primate species as models of human bacterial sepsis.

Authors:  Lingye Chen; Karen E Welty-Wolf; Bryan D Kraft
Journal:  Lab Anim (NY)       Date:  2019-01-14       Impact factor: 12.625

Review 9.  Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research.

Authors:  Guoping Feng; Frances E Jensen; Henry T Greely; Hideyuki Okano; Stefan Treue; Angela C Roberts; James G Fox; Sarah Caddick; Mu-Ming Poo; William T Newsome; John H Morrison
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-19       Impact factor: 11.205

  9 in total

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