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Literature DB >> 2903216

Identification of CD2-/CD3+ T cells in fetal human tissue.

Abstract

From 1 to 23% of fetal human spleen or thymus cells (from the 20th to 24th week of gestation) were found to display a previously unrecognized CD2-/CD3+ phenotype. IL-2-dependent, long-term clones of CD2-/3+ T cells did not react with a panel of anti-CD2 mAbs and did not form rosettes with sheep erythrocytes. These results show that (a) significant numbers of CD2-/3+ T cells are present in fetal human spleen and/or thymus; and (b) in contrast to the widely accepted view, expression of CD2 is not a prerequisite for the expression of the CD3 molecular complex on human T cells.

Entities: Gene Species

Mesh：

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Year: 1988 PMID： 2903216 PMCID： PMC2189098 DOI： 10.1084/jem.168.5.1941

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

13 in total

Review 1. Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways.

Authors: A Alcover; D Ramarli; N E Richardson; H C Chang; E L Reinherz
Journal: Immunol Rev Date: 1987-02 Impact factor: 12.988

2. Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.

Authors: T Hünig; G Tiefenthaler; K H Meyer zum Büschenfelde; S C Meuer
Journal: Nature Date: 1987 Mar 19-25 Impact factor: 49.962

3. The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

Authors: J B Breitmeyer; J F Daley; H B Levine; S F Schlossman
Journal: J Immunol Date: 1987-11-01 Impact factor: 5.422

4. Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation.

Authors: A Moretta; A Poggi; D Olive; C Bottino; C Fortis; G Pantaleo; L Moretta
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

5. Direct evidence for a receptor-ligand interaction between the T-cell surface antigen CD2 and lymphocyte-function-associated antigen 3.

Authors: Y Takai; M L Reed; S J Burakoff; S H Herrmann
Journal: Proc Natl Acad Sci U S A Date: 1987-10 Impact factor: 11.205

3. A novel subset of CD2-, CD3/T cell receptor alpha/beta+ human peripheral blood T cells. Phenotypic and functional characterization of interleukin 2-dependent CD2-CD3+ T cell clones.

Authors: D Kabelitz; P Conradt; S Schondelmaier; H Wagner; R Haars
Journal: J Exp Med Date: 1989-08-01 Impact factor: 14.307

4. Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment.

Authors: B F Haynes; C S Heinly
Journal: J Exp Med Date: 1995-04-01 Impact factor: 14.307

4 in total

Identification of CD2-/CD3+ T cells in fetal human tissue.

Review 1. Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways.

2. Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.

3. The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells.

4. Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation.

5. Direct evidence for a receptor-ligand interaction between the T-cell surface antigen CD2 and lymphocyte-function-associated antigen 3.

6. An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.

7. A monoclonal anti-pan-T-cell antibody. In vitro and in vivo studies.

8. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3.

9. Identification of a CD2- CD3+ T cell receptor-gamma+ peripheral blood lymphocyte subpopulation.

10. A novel subset of human lymphocytes with a T cell receptor-gamma complex.

1. A unique syndrome of immunodeficiency and autoimmunity associated with absent T cell CD2 expression.

2. Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny.

3. A novel subset of CD2-, CD3/T cell receptor alpha/beta+ human peripheral blood T cells. Phenotypic and functional characterization of interleukin 2-dependent CD2-CD3+ T cell clones.

4. Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment.