Seung Jin Han1, Soo-Kyung Kim2, Wilfred Y Fujimoto3, Steven E Kahn4, Donna L Leonetti5, Edward J Boyko6. 1. Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea; Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA. 2. Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. 3. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. 4. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA; Hospital and Specialty Medicine Service, VA Puget Sound Health Care System, Seattle, WA, USA. 5. Department of Anthropology, University of Washington, Seattle, WA, USA. 6. Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: eboyko@uw.edu.
Abstract
AIM: We investigated the association between combined changes of visceral fat and thigh muscle over 5 years and incident type 2 diabetes in a prospective study of Japanese Americans. METHODS: We followed 420 nondiabetic Japanese American subjects for 5 years and assessed visceral fat and thigh muscle by computed tomography (CT) at baseline and at 5 years. We categorized study subjects into 4 body composition change groups: visceral fat loss/thigh muscle gain (VF-loss/TM-gain), visceral fat loss/thigh muscle loss (VF-loss/TM-loss), visceral fat gain/thigh muscle gain (VF-gain/TM-gain), and visceral fat gain/thigh muscle loss (VF-gain/TM-loss) by combining changes from baseline in CT measured visceral fat and estimated thigh muscle areas. We fit a logistic regression model to examine the association between body composition categories and the development of incident type 2 diabetes at 5 years. RESULTS: Cumulative incidence of type 2 diabetes was 9.8% at 5 years. VF-gain/TM-gain and VF-loss/TM-loss groups had higher risk for incident type 2 diabetes in a model adjusted for age, sex, family history of diabetes, and body mass index compared to VF-loss/TM-gain group as the reference category (OR=6.83 (1.85-25.17), 4.55 (1.06-19.48), respectively). However, the VF-gain/TM-loss group did not show a significant association with the odds of incident diabetes (3.24; 95% CI. 0.78-13.47). CONCLUSIONS: Concordant gain or loss in visceral fat and thigh muscle was related to higher risk of incident type 2 diabetes compared to the reference combination of loss of visceral fat and gain of thigh muscle in Japanese Americans. Published by Elsevier B.V.
AIM: We investigated the association between combined changes of visceral fat and thigh muscle over 5 years and incident type 2 diabetes in a prospective study of Japanese Americans. METHODS: We followed 420 nondiabetic Japanese American subjects for 5 years and assessed visceral fat and thigh muscle by computed tomography (CT) at baseline and at 5 years. We categorized study subjects into 4 body composition change groups: visceral fat loss/thigh muscle gain (VF-loss/TM-gain), visceral fat loss/thigh muscle loss (VF-loss/TM-loss), visceral fat gain/thigh muscle gain (VF-gain/TM-gain), and visceral fat gain/thigh muscle loss (VF-gain/TM-loss) by combining changes from baseline in CT measured visceral fat and estimated thigh muscle areas. We fit a logistic regression model to examine the association between body composition categories and the development of incident type 2 diabetes at 5 years. RESULTS: Cumulative incidence of type 2 diabetes was 9.8% at 5 years. VF-gain/TM-gain and VF-loss/TM-loss groups had higher risk for incident type 2 diabetes in a model adjusted for age, sex, family history of diabetes, and body mass index compared to VF-loss/TM-gain group as the reference category (OR=6.83 (1.85-25.17), 4.55 (1.06-19.48), respectively). However, the VF-gain/TM-loss group did not show a significant association with the odds of incident diabetes (3.24; 95% CI. 0.78-13.47). CONCLUSIONS: Concordant gain or loss in visceral fat and thigh muscle was related to higher risk of incident type 2 diabetes compared to the reference combination of loss of visceral fat and gain of thigh muscle in Japanese Americans. Published by Elsevier B.V.
Authors: Lando L J Koppes; Jacqueline M Dekker; Henk F J Hendriks; Lex M Bouter; Robert J Heine Journal: Diabetes Care Date: 2005-03 Impact factor: 19.112
Authors: Marieke B Snijder; Jacqueline M Dekker; Marjolein Visser; Lex M Bouter; Coen D A Stehouwer; Piet J Kostense; John S Yudkin; Robert J Heine; Giel Nijpels; Jacob C Seidell Journal: Am J Clin Nutr Date: 2003-05 Impact factor: 7.045