Małgorzata Szczuko1, Marta Zapałowska-Chwyć2, Arleta Drozd3, Dominika Maciejewska3, Andrzej Starczewski2, Ewa Stachowska3. 1. Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Poland. Electronic address: malgorzata.szczuko@pum.edu.pl. 2. Clinic of Gynecology and Urogynecology, Pomeranian Medical University in Szczecin, Poland. 3. Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Poland.
Abstract
CONTEXT: The aetiology and pathogenesis polycystic ovary syndrome (PCOS) remain uncertain and thus the relative studies are still crucial. OBJECTIVE: Our aim was to analyse the fatty acids profiles of the main phospholipids species in serum from women with PCOS classified into phenotypes, and to diagnose women more susceptible to the occurrence of inflammatory state. DESIGN: PCOS screening tests were performed in The Clinic of Gynecology and Urogynecology of Pomeranian Medical University in the 2014-2015 years. SETTING: The study are designed for general community and a primary care or referral center. PATIENTS: 39 patients with PCOS, diagnosed according to Rotterdam's criteria, and 14 healthy women, as a control group, participated in this study. Fatty acid profiles were investigated using gas chromatography. A total of 36 fatty acids and their derivatives were identified and quantified. MAIN OUTCOME MEASURE: Changes in fatty acids profile in plasma from women with PCOS phenotypes are not identical. RESULTS: The analyses showed lowered level of total SFA, increase in the concentration of caprylic acid and the activation of palmitic and oleic acids pathways. The level of nervonic acid was several times higher than in the control group, and the levels of behenic and tricosanoic acids were reduced. CONCLUSIONS: In both phenotypes the alternative metabolic pathways of oleic acid were activated, but they were more pronounced in women with proper level of androgens. Gamma-linolenic acid (C18:3n6) can be a factor protecting hyperandrogenic women.
CONTEXT: The aetiology and pathogenesis polycystic ovary syndrome (PCOS) remain uncertain and thus the relative studies are still crucial. OBJECTIVE: Our aim was to analyse the fatty acids profiles of the main phospholipids species in serum from women with PCOS classified into phenotypes, and to diagnose women more susceptible to the occurrence of inflammatory state. DESIGN:PCOS screening tests were performed in The Clinic of Gynecology and Urogynecology of Pomeranian Medical University in the 2014-2015 years. SETTING: The study are designed for general community and a primary care or referral center. PATIENTS: 39 patients with PCOS, diagnosed according to Rotterdam's criteria, and 14 healthy women, as a control group, participated in this study. Fatty acid profiles were investigated using gas chromatography. A total of 36 fatty acids and their derivatives were identified and quantified. MAIN OUTCOME MEASURE: Changes in fatty acids profile in plasma from women with PCOS phenotypes are not identical. RESULTS: The analyses showed lowered level of total SFA, increase in the concentration of caprylic acid and the activation of palmitic and oleic acids pathways. The level of nervonic acid was several times higher than in the control group, and the levels of behenic and tricosanoic acids were reduced. CONCLUSIONS: In both phenotypes the alternative metabolic pathways of oleic acid were activated, but they were more pronounced in women with proper level of androgens. Gamma-linolenic acid (C18:3n6) can be a factor protecting hyperandrogenic women.
Authors: Ilhame Diboun; Manjunath Ramanjaneya; Lina Ahmed; Mohammed Bashir; Alexandra E Butler; Omar Albagha; Abdul Badi Abou-Samra; Stephen L Atkin; Nayef A Mazloum; Mohamed A Elrayess Journal: Front Endocrinol (Lausanne) Date: 2021-06-15 Impact factor: 5.555
Authors: Dariusz Kotlęga; Barbara Peda; Joanna Palma; Agnieszka Zembroń-Łacny; Monika Gołąb-Janowska; Marta Masztalewicz; Przemysław Nowacki; Małgorzata Szczuko Journal: Int J Environ Res Public Health Date: 2021-06-16 Impact factor: 3.390
Authors: Anna Rajska; Magdalena Buszewska-Forajta; Dominik Rachoń; Michał Jan Markuszewski Journal: Int J Mol Sci Date: 2020-07-09 Impact factor: 5.923