Katerina Hufendiek1,2, Maria-Andreea Gamulescu3, Karsten Hufendiek3,4, Horst Helbig3, David Märker3. 1. Department of Ophthalmology, University Medical Center Regensburg, Regensburg, Germany. hufendiek.katerina@mh-hannover.de. 2. University Eye Hospital, Hannover Medical School, Hannover, Germany. hufendiek.katerina@mh-hannover.de. 3. Department of Ophthalmology, University Medical Center Regensburg, Regensburg, Germany. 4. University Eye Hospital, Hannover Medical School, Hannover, Germany.
Abstract
PURPOSE: To classify and characterize AMN lesions with SD-OCT during a follow-up as long as 5 years. METHODS: Retrospective study of 14 patients (18 eyes) with special focus on SD-OCT. We measured thickness of inner nuclear layer (INL), outer retinal layer (ONL), and hyperreflective band at baseline and during follow-up. AMN lesions were classified as type 1 and type 2. RESULTS: Of 14 patients (six males, eight females, mean age 29.7 years), three patients (four eyes) had type 1 and nine (12 eyes) had type 2. Two patients did not meet the criteria for AMN type 1 or 2 and were therefore classified as new subtype of AMN. In all patients, statistically significant thinning of ONL and INL was observable. Mean ONL of all patients was 90.2 ± 7.81 and 72.3 ± 15.64 μm (p < 0.05) during follow-up; mean INL was 54.4 ± 10.71 and 37.5 ± 6.18 μm (p < 0.05) in the course. In the subgroup analysis in AMN type 2, the thinning of both ONL and INL was also statistically significant (mean ONL: 87.4 ± 6.02 and 71.6 ± 12.7 μm (p < 0.05); mean INL: 48.5 ± 5.04 and 38.5 ± 5.6 μm (p < 0.05)) in the course. CONCLUSION: SD-OCT allows for classification, characterization, and further understanding of AMN lesions. Up to now, this is one of the largest AMN case series differentiating into different subtypes and following up for up to 5 years. Furthermore, we describe a new AMN subtype characterized by initially clinically visible yellowish parafoveal lesions, subtle pigmentary changes at late stage, lack of classic dark appearance on IR reflectance, involvement of RPE/Bruch's complex, and disruption of ellipsoid zone and interdigitation zone. The patients suffered from a prolonged visual impairment and paracentral scotomata. We propose the term AMN type 3 or "paracentral acute outer maculopathy."
PURPOSE: To classify and characterize AMN lesions with SD-OCT during a follow-up as long as 5 years. METHODS: Retrospective study of 14 patients (18 eyes) with special focus on SD-OCT. We measured thickness of inner nuclear layer (INL), outer retinal layer (ONL), and hyperreflective band at baseline and during follow-up. AMN lesions were classified as type 1 and type 2. RESULTS: Of 14 patients (six males, eight females, mean age 29.7 years), three patients (four eyes) had type 1 and nine (12 eyes) had type 2. Two patients did not meet the criteria for AMN type 1 or 2 and were therefore classified as new subtype of AMN. In all patients, statistically significant thinning of ONL and INL was observable. Mean ONL of all patients was 90.2 ± 7.81 and 72.3 ± 15.64 μm (p < 0.05) during follow-up; mean INL was 54.4 ± 10.71 and 37.5 ± 6.18 μm (p < 0.05) in the course. In the subgroup analysis in AMN type 2, the thinning of both ONL and INL was also statistically significant (mean ONL: 87.4 ± 6.02 and 71.6 ± 12.7 μm (p < 0.05); mean INL: 48.5 ± 5.04 and 38.5 ± 5.6 μm (p < 0.05)) in the course. CONCLUSION:SD-OCT allows for classification, characterization, and further understanding of AMN lesions. Up to now, this is one of the largest AMN case series differentiating into different subtypes and following up for up to 5 years. Furthermore, we describe a new AMN subtype characterized by initially clinically visible yellowish parafoveal lesions, subtle pigmentary changes at late stage, lack of classic dark appearance on IR reflectance, involvement of RPE/Bruch's complex, and disruption of ellipsoid zone and interdigitation zone. The patients suffered from a prolonged visual impairment and paracentral scotomata. We propose the term AMN type 3 or "paracentral acute outer maculopathy."
Authors: Amani A Fawzi; Rajeev R Pappuru; David Sarraf; Philip Phuc Le; Colin A McCannel; Lucia Sobrin; Debra A Goldstein; Scott Honowitz; Alex C Walsh; Srinivas R Sadda; Lee M Jampol; Dean Eliott Journal: Retina Date: 2012-09 Impact factor: 4.256
Authors: David Sarraf; Ehsan Rahimy; Amani A Fawzi; Elliott Sohn; Irene Barbazetto; David N Zacks; Robert A Mittra; James M Klancnik; Sarah Mrejen; Naomi R Goldberg; Robert Beardsley; John A Sorenson; K Bailey Freund Journal: JAMA Ophthalmol Date: 2013-10 Impact factor: 7.389