| Literature DB >> 29030765 |
Matteo Gastaldi1, Elisabetta Zardini1, Rosaria Leante2, Maddalena Ruggieri2, Gianna Costa3, Eleonora Cocco3, Giovanna De Luca4, Ivana Cataldo4, Tiziana Biagioli5, Clara Ballerini6, Massimiliano Castellazzi7, Enrico Fainardi6, Paola Pettini8, Mauro Zaffaroni8, Debora Giunti9, Elisabetta Capello9, Gaetano Bernardi10, Emilio Ciusani10, Claudia Giannotta11, Eduardo Nobile-Orazio11, Elena Bazzigaluppi12, Gabriella Passerini12, Roberta Bedin13, Patrizia Sola13, Rinaldo Brivio14, Guido Cavaletti15, Arianna Sala16, Antonio Bertolotto16, Gaetano Desina17, Maurizio A Leone17, Sara Mariotto18, Sergio Ferrari18, Andreina Paternoster19, Davide Giavarina19, Francesco Lolli6, Diego Franciotta20.
Abstract
This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.Entities:
Keywords: Intrathecal IgG synthesis; Isoelectric focusing; Laboratory diagnostics; Multiple sclerosis; Neuroimmunology
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Year: 2017 PMID： 29030765 DOI： 10.1007/s10072-017-3034-2
Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307