Kiran Khush1, Shirin Zarafshar2. 1. Stanford University School of Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA, 94305, USA. kiran@stanford.edu. 2. Stanford University School of Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA, 94305, USA.
Abstract
PURPOSE OF REVIEW: Acute rejection is one of the most feared complications of cardiac transplantation. Developing non-invasive methods for detection and surveillance of acute rejection have long been a goal for post-transplant care. RECENT FINDINGS: Here, we will review molecular diagnostic tests that are currently in use or under development to diagnose acute cellular rejection after cardiac transplantation. Gene expression, microRNA, molecular microscope, and cell-free DNA assays offer non-invasive alternatives to the endomyocardial biopsy for acute rejection surveillance.
PURPOSE OF REVIEW: Acute rejection is one of the most feared complications of cardiac transplantation. Developing non-invasive methods for detection and surveillance of acute rejection have long been a goal for post-transplant care. RECENT FINDINGS: Here, we will review molecular diagnostic tests that are currently in use or under development to diagnose acute cellular rejection after cardiac transplantation. Gene expression, microRNA, molecular microscope, and cell-free DNA assays offer non-invasive alternatives to the endomyocardial biopsy for acute rejection surveillance.
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