On OX40 and PD-1 Combination: Why Should OX40 Be First in Sequence?

The larger fraction of patients treated with immune checkpoint inhibitors remain nonresponding eventually. Combination of checkpoint inhibitor and costimulatory antibodies is thought additive, but for such effect, they may require to be given in the right sequence. Clin Cancer Res; 23(20); 5999-6001. ©2017 AACRSee related article by Messenheimer et al., p. 6165. ©2017 American Association for Cancer Research.