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Literature DB >> 29029851

Arresting Evolution.

Abstract

Evolution in the form of selective breeding has long been harnessed as a useful tool by humans. However, rapid evolution can also be a danger to our health and a stumbling block for biotechnology. Unwanted evolution can underlie the emergence of drug and pesticide resistance, cancer, and weeds. It makes live vaccines and engineered cells inherently unreliable and unpredictable, and therefore potentially unsafe. Yet, there are strategies that have been and can possibly be used to stop or slow many types of evolution. We review and classify existing population genetics-inspired methods for arresting evolution. Then, we discuss how genome editing techniques enable a radically new set of approaches to limit evolution.

Entities: CellLine Chemical Disease Gene Species

Keywords: drug resistance; evolution proof; gene drive; genome engineering; refuge crop; synthetic biology

Mesh：

Year: 2017 PMID： 29029851 PMCID： PMC5777322 DOI： 10.1016/j.tig.2017.09.008

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

61 in total

9. Innovation in an E. coli evolution experiment is contingent on maintaining adaptive potential until competition subsides.

Authors: Dacia Leon; Simon D'Alton; Erik M Quandt; Jeffrey E Barrick
Journal: PLoS Genet Date: 2018-04-12 Impact factor: 5.917

Review 10. Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.

Authors: Dhara Malavia; Neil A R Gow; Jane Usher
Journal: Microorganisms Date: 2020-05-26

Arresting Evolution.

1. Mutation selection and the natural history of cancer.

2. Relative fitness can decrease in evolving asexual populations of S. cerevisiae.

Review 3. The nature of selection during plant domestication.

4. Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus.

5. The effect of gene overlapping on the rate of RNA virus evolution.

6. Mutation load under vegetative reproduction and cytoplasmic inheritance.

7. Large-scale test of the natural refuge strategy for delaying insect resistance to transgenic Bt crops.

8. Recoded organisms engineered to depend on synthetic amino acids.

9. Fitness of transgenic mosquito Aedes aegypti males carrying a dominant lethal genetic system.

10. How to make evolution-proof insecticides for malaria control.

1. Synthetic addiction extends the productive life time of engineered Escherichia coli populations.

2. Directed evolution of Escherichia coli with lower-than-natural plasmid mutation rates.

3. Development of a multi-locus CRISPR gene drive system in budding yeast.

4. Evolution and containment of transmissible recombinant vector vaccines.

5. The Synthetic Microbiology Caucus: from abstract ideas to turning microbes into cellular machines and back.

Review 6. The future of self-selecting and stable fermentations.

7. Suppressing evolution in genetically engineered systems through repeated supplementation.

8. Biochemical mechanisms determine the functional compatibility of heterologous genes.

9. Innovation in an E. coli evolution experiment is contingent on maintaining adaptive potential until competition subsides.

Review 10. Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis.