N A Al-Eesa1, F S L Wong2, A Johal1, R G Hill1. 1. Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry, Centre for Oral Bioengineering, Mile End Road, London E1 4NS, UK. 2. Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry, Centre for Oral Bioengineering, Mile End Road, London E1 4NS, UK. Electronic address: f.s.l.wong@qmul.ac.uk.
Abstract
OBJECTIVE: Dental materials that release calcium, phosphate and fluoride ions could prevent demineralisation and/or enhance remineralisation of enamel. The objective was to develop a novel bioactive glass (BAG) resin and investigate pH changes and ion release in 3 immersion media. METHODS: Quench melt derived BAG (35.25% SiO2, 6% Na2O, 43% CaO, 5.75% P2O5, and 10% CaF2) was incorporated into a resin (42.25% BisEMA, 55% TEGDMA, 0.25% DMAEM, 0.5% camphorquinone and 2% 4-Meta), with a filler load of 80% by weight. Ninety composite disks for each BAG loading of 80%, 60%, 50%, 40%, 20%, and 0% were made and each disk was immersed in 10ml of either tris buffer (TB), or artificial saliva at pH=7 (AS7) or pH=4 (AS4), n=30 for each solution. Three disks of each loading were taken from each of the solutions, at ten time points (6h-6months), for measurement of pH, fluoride, calcium and phosphate. RESULTS: The BAG adhesive raised the pH in all the solutions, release Ca, PO4 and F ions especially in AS4. The rise in pH and the release of Ca and F are directly related to the BAG loading and the time of immersion. The pH and the ion releases were maintained and continued over 6months. SIGNIFICANCE: Unlike glass ionomer resins, favourable ions F, Ca and PO4 releases were maintained over a long time period especially in acidic condition for this novel BAG-resin composite. This indicates the resin has the potential to prevent formation and progression of early caries lesions.
OBJECTIVE: Dental materials that release calcium, phosphate and fluoride ions could prevent demineralisation and/or enhance remineralisation of enamel. The objective was to develop a novel bioactive glass (BAG) resin and investigate pH changes and ion release in 3 immersion media. METHODS: Quench melt derived BAG (35.25% SiO2, 6% Na2O, 43% CaO, 5.75% P2O5, and 10% CaF2) was incorporated into a resin (42.25% BisEMA, 55% TEGDMA, 0.25% DMAEM, 0.5% camphorquinone and 2% 4-Meta), with a filler load of 80% by weight. Ninety composite disks for each BAG loading of 80%, 60%, 50%, 40%, 20%, and 0% were made and each disk was immersed in 10ml of either tris buffer (TB), or artificial saliva at pH=7 (AS7) or pH=4 (AS4), n=30 for each solution. Three disks of each loading were taken from each of the solutions, at ten time points (6h-6months), for measurement of pH, fluoride, calcium and phosphate. RESULTS: The BAG adhesive raised the pH in all the solutions, release Ca, PO4 and F ions especially in AS4. The rise in pH and the release of Ca and F are directly related to the BAG loading and the time of immersion. The pH and the ion releases were maintained and continued over 6months. SIGNIFICANCE: Unlike glass ionomer resins, favourable ions F, Ca and PO4 releases were maintained over a long time period especially in acidic condition for this novel BAG-resin composite. This indicates the resin has the potential to prevent formation and progression of early caries lesions.
Authors: Mara Elena Rusnac; Cristina Gasparik; Alexandra Iulia Irimie; Alexandru Graţian Grecu; Anca Ştefania Mesaroş; Diana Dudea Journal: Med Pharm Rep Date: 2019-04-25
Authors: Ke Zhang; Bashayer Baras; Christopher D Lynch; Michael D Weir; Mary Anne S Melo; Yuncong Li; Mark A Reynolds; Yuxing Bai; Lin Wang; Suping Wang; Hockin H K Xu Journal: Materials (Basel) Date: 2018-09-17 Impact factor: 3.623