OBJECTIVE: HIV-associated neurocognitive disorders (HAND) have historically been characterized as a subcortical condition that does not affect semantic memory; however, recent evidence suggests that the cortical regions that support semantic memory may be affected in HIV. METHOD: The current study examined the effects of HAND on semantic memory in 85 HIV+ individuals with HAND, 193 HIV+ individuals without HAND, and 181 HIV- individuals who completed the Boston Naming Test (BNT) and the Famous Faces subtest of the Kauffman Adolescent and Adult Intelligence Test (KAIT-FF). RESULTS: Linear regressions revealed a significant adverse effect of HAND on total scores on the BNT and the KAIT-FF (all ps < .01). Analyses of BNT errors showed that individuals with HAND committed more semantically related errors as compared to the other two study groups (all ps < .05). However, there were no group differences in rates of visually based errors, which are more commonly observed in traditional subcortical diseases (all ps > .10). CONCLUSIONS: Results indicate that HAND may impose adverse effects on individuals' object naming and identification abilities suggestive of mild semantic deficits that parallel traditional cortical diseases such as Alzheimer's disease.
OBJECTIVE: HIV-associated neurocognitive disorders (HAND) have historically been characterized as a subcortical condition that does not affect semantic memory; however, recent evidence suggests that the cortical regions that support semantic memory may be affected in HIV. METHOD: The current study examined the effects of HAND on semantic memory in 85 HIV+ individuals with HAND, 193 HIV+ individuals without HAND, and 181 HIV- individuals who completed the Boston Naming Test (BNT) and the Famous Faces subtest of the Kauffman Adolescent and Adult Intelligence Test (KAIT-FF). RESULTS: Linear regressions revealed a significant adverse effect of HAND on total scores on the BNT and the KAIT-FF (all ps < .01). Analyses of BNT errors showed that individuals with HAND committed more semantically related errors as compared to the other two study groups (all ps < .05). However, there were no group differences in rates of visually based errors, which are more commonly observed in traditional subcortical diseases (all ps > .10). CONCLUSIONS: Results indicate that HAND may impose adverse effects on individuals' object naming and identification abilities suggestive of mild semantic deficits that parallel traditional cortical diseases such as Alzheimer's disease.
Authors: Juan Carlos Arango-Lasprilla; Heather Rogers; Jean Lengenfelder; John Deluca; Sonia Moreno; Francisco Lopera Journal: Arch Clin Neuropsychol Date: 2005-09-06 Impact factor: 2.813
Authors: Steven Paul Woods; Erin E Morgan; Matthew Dawson; J Cobb Scott; Igor Grant Journal: J Clin Exp Neuropsychol Date: 2006-08 Impact factor: 2.475
Authors: G Peavy; D Jacobs; D P Salmon; N Butters; D C Delis; M Taylor; P Massman; J C Stout; W C Heindel; D Kirson Journal: J Clin Exp Neuropsychol Date: 1994-08 Impact factor: 2.475
Authors: Douglas A Green; Eliezer Masliah; Harry V Vinters; Pouneh Beizai; David J Moore; Cristian L Achim Journal: AIDS Date: 2005-03-04 Impact factor: 4.177
Authors: Eva M Müller-Oehring; Jui-Yang Hong; Kathleen L Poston; Helen M Brontë-Stewart; Edith V Sullivan; Lawrence McGlynn; Tilman Schulte Journal: Brain Imaging Behav Date: 2022-03-16 Impact factor: 3.224
Authors: Kelli L Sullivan; David P Sheppard; Briana Johnson; Jennifer L Thompson; Luis D Medina; Clayton Neighbors; Rodrigo Hasbun; Erin E Morgan; Shayne Loft; Steven Paul Woods Journal: Neuropsychology Date: 2021-04-22 Impact factor: 3.424