Alexandra M Ortiz1, Jason M Brenchley. 1. Laboratory of Parasitology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Abstract
PURPOSE OF REVIEW: The article describes recent advances in understanding the causes and consequences of microbial translocation in HIV and simian immunodeficiency virus infections. RECENT FINDINGS: Persistent microbial translocation contributes to aberrant immune activation in immunodeficiency lentiviral infections and thereby, pathogenesis and mortality. Efforts to delineate the circumstances surrounding translocation have benefited from use of simian immunodeficiency virus-infected nonhuman primates and highlight the overwhelming immunologic diversion caused by translocating microbes. The use of therapeutics aimed at reducing microbial translocation show promise and will benefit from continued research into the mechanisms that promote systemic microbial dissemination in treated and untreated infections. SUMMARY: Insights into the source and identity of translocating microbes in lentiviral infections continue to enhance the development of adjunct therapeutics.
PURPOSE OF REVIEW: The article describes recent advances in understanding the causes and consequences of microbial translocation in HIV and simian immunodeficiency virus infections. RECENT FINDINGS: Persistent microbial translocation contributes to aberrant immune activation in immunodeficiency lentiviral infections and thereby, pathogenesis and mortality. Efforts to delineate the circumstances surrounding translocation have benefited from use of simian immunodeficiency virus-infected nonhuman primates and highlight the overwhelming immunologic diversion caused by translocating microbes. The use of therapeutics aimed at reducing microbial translocation show promise and will benefit from continued research into the mechanisms that promote systemic microbial dissemination in treated and untreated infections. SUMMARY: Insights into the source and identity of translocating microbes in lentiviral infections continue to enhance the development of adjunct therapeutics.
Authors: Scott A Handley; Chandni Desai; Guoyan Zhao; Lindsay Droit; Cynthia L Monaco; Andrew C Schroeder; Joseph P Nkolola; Megan E Norman; Andrew D Miller; David Wang; Dan H Barouch; Herbert W Virgin Journal: Cell Host Microbe Date: 2016-03-09 Impact factor: 21.023
Authors: Collin L Ellis; Zhong-Min Ma; Surinder K Mann; Chin-Shang Li; Jian Wu; Thomas H Knight; Tammy Yotter; Timothy L Hayes; Archana H Maniar; Paolo V Troia-Cancio; Heather A Overman; Natalie J Torok; Anthony Albanese; John C Rutledge; Christopher J Miller; Richard B Pollard; David M Asmuth Journal: J Acquir Immune Defic Syndr Date: 2011-08-15 Impact factor: 3.731
Authors: Guido Silvestri; Donald L Sodora; Richard A Koup; Mirko Paiardini; Shawn P O'Neil; Harold M McClure; Silvija I Staprans; Mark B Feinberg Journal: Immunity Date: 2003-03 Impact factor: 31.745
Authors: Nichole R Klatt; Lauren A Canary; Xiaoyong Sun; Carol L Vinton; Nicholas T Funderburg; David R Morcock; Mariam Quiñones; Clayton B Deming; Molly Perkins; Daria J Hazuda; Michael D Miller; Michael M Lederman; Julie A Segre; Jeffrey D Lifson; Elias K Haddad; Jacob D Estes; Jason M Brenchley Journal: J Clin Invest Date: 2013-01-16 Impact factor: 14.808
Authors: Jacob D Estes; Levelle D Harris; Nichole R Klatt; Brian Tabb; Stefania Pittaluga; Mirko Paiardini; G Robin Barclay; Jeremy Smedley; Rhonda Pung; Kenneth M Oliveira; Vanessa M Hirsch; Guido Silvestri; Daniel C Douek; Christopher J Miller; Ashley T Haase; Jeffrey Lifson; Jason M Brenchley Journal: PLoS Pathog Date: 2010-08-19 Impact factor: 6.823
Authors: Simone S Li; Ana Zhu; Vladimir Benes; Paul I Costea; Rajna Hercog; Falk Hildebrand; Jaime Huerta-Cepas; Max Nieuwdorp; Jarkko Salojärvi; Anita Y Voigt; Georg Zeller; Shinichi Sunagawa; Willem M de Vos; Peer Bork Journal: Science Date: 2016-04-29 Impact factor: 47.728
Authors: Jan Kristoff; George Haret-Richter; Dongzhu Ma; Ruy M Ribeiro; Cuiling Xu; Elaine Cornell; Jennifer L Stock; Tianyu He; Adam D Mobley; Samantha Ross; Anita Trichel; Cara Wilson; Russell Tracy; Alan Landay; Cristian Apetrei; Ivona Pandrea Journal: J Clin Invest Date: 2014-05-16 Impact factor: 14.808
Authors: N R Klatt; J D Estes; X Sun; A M Ortiz; J S Barber; L D Harris; B Cervasi; L K Yokomizo; L Pan; C L Vinton; B Tabb; L A Canary; Q Dang; V M Hirsch; G Alter; Y Belkaid; J D Lifson; G Silvestri; J D Milner; M Paiardini; E K Haddad; J M Brenchley Journal: Mucosal Immunol Date: 2012-05-30 Impact factor: 7.313
Authors: Alexandra M Ortiz; Jacob K Flynn; Sarah R DiNapoli; Ornella Sortino; Ivan Vujkovic-Cvijin; Yasmine Belkaid; Irini Sereti; Jason M Brenchley Journal: J Virol Date: 2019-08-28 Impact factor: 5.103
Authors: Ornella Sortino; Nittaya Phanuphak; Alexandra Schuetz; Alexandra M Ortiz; Nitiya Chomchey; Yasmine Belkaid; Jacquice Davis; Harry A Mystakelis; Mariam Quiñones; Claire Deleage; Brian Ingram; Rungsun Rerknimitr; Suteeraporn Pinyakorn; Adam Rupert; Merlin L Robb; Jintanat Ananworanich; Jason Brenchley; Irini Sereti Journal: Open Forum Infect Dis Date: 2019-08-21 Impact factor: 3.835
Authors: Rachele M Bochart; Kathleen Busman-Sahay; Stephen Bondoc; David W Morrow; Alexandra M Ortiz; Christine M Fennessey; Miranda B Fischer; Oriene Shiel; Tonya Swanson; Christine M Shriver-Munsch; Hugh B Crank; Kimberly M Armantrout; Aaron M Barber-Axthelm; Charlotte Langner; Cassandra R Moats; Caralyn S Labriola; Rhonda MacAllister; Michael K Axthelm; Jason M Brenchley; Brandon F Keele; Jacob D Estes; Scott G Hansen; Jeremy V Smedley Journal: PLoS Pathog Date: 2021-05-10 Impact factor: 7.464
Authors: Anna C Belkina; Alina Starchenko; Katherine A Drake; Elizabeth A Proctor; Riley M F Pihl; Alex Olson; Douglas A Lauffenburger; Nina Lin; Jennifer E Snyder-Cappione Journal: Front Immunol Date: 2018-12-05 Impact factor: 8.786
Authors: Alexandra M Ortiz; Jacob K Flynn; Sarah R DiNapoli; Ivan Vujkovic-Cvijin; Carly E Starke; Stephen H Lai; MacKenzie E Long; Ornella Sortino; Carol L Vinton; Joseph C Mudd; Leslie Johnston; Kathleen Busman-Sahay; Yasmine Belkaid; Jacob D Estes; Jason M Brenchley Journal: Nat Med Date: 2018-07-30 Impact factor: 53.440