| Literature DB >> 29027714 |
Dongyin Chen1,2, Fengguo Xu1, Pu Zhang1, Jie Deng1, Hongbin Sun1, Xiaoan Wen1, Jun Liu1.
Abstract
A practical synthesis of α-amyrin (1), β-amyrin (2), and lupeol (3) was accomplished in total yields of 32, 42, and 40% starting from easily available ursolic acid (4), oleanolic acid (5), and betulin (6), respectively. Remarkably, these three natural pentacyclic triterpenes exhibited potential inhibitory activity against human oxidosqualene cyclase.Entities:
Keywords: Lupeol; Oxidosqualene cyclase inhibitor; Synthesis; α-Amyrin; β-Amyrin
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Year: 2017 PMID： 29027714 DOI： 10.1002/ardp.201700178
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751