BACKGROUND: Exposure to petroleum products has been shown to have significant adverse effects on the liver which can manifest either as morphological or physiological changes. OBJECTIVES: The aim of the study was to assess the effects of chronic exposure to some petroleum products on the liver of exposed workers using sonography and to determine whether biochemical assessments underestimated hepatotoxicity. METHODS: Abdominal ultrasound was performed on 415 exposed workers in order to evaluate liver echogenicity and size. Also, biochemical assessment of the liver was done to evaluate its function. RESULTS: Statistically significant increase in the liver parenchymal echogenicity and the liver size was seen in the exposed workers compared with control (p ≤ 0.05). These increased as the exposure duration increased. It was also noted that out of 16.87% (N=70) exposed workers with abnormal liver echopattern, only 2.65% (N=11) had alanine aminotransferase above the reference range. CONCLUSION: The study revealed evidence of ultrasound detectable hepatotoxicity among the exposed subjects. Sonography appeared to detect petroleum products-induced hepatic toxicity more than biochemical assays suggesting that biochemical assessment may have underestimated toxicity.
BACKGROUND: Exposure to petroleum products has been shown to have significant adverse effects on the liver which can manifest either as morphological or physiological changes. OBJECTIVES: The aim of the study was to assess the effects of chronic exposure to some petroleum products on the liver of exposed workers using sonography and to determine whether biochemical assessments underestimated hepatotoxicity. METHODS: Abdominal ultrasound was performed on 415 exposed workers in order to evaluate liver echogenicity and size. Also, biochemical assessment of the liver was done to evaluate its function. RESULTS: Statistically significant increase in the liver parenchymal echogenicity and the liver size was seen in the exposed workers compared with control (p ≤ 0.05). These increased as the exposure duration increased. It was also noted that out of 16.87% (N=70) exposed workers with abnormal liver echopattern, only 2.65% (N=11) had alanine aminotransferase above the reference range. CONCLUSION: The study revealed evidence of ultrasound detectable hepatotoxicity among the exposed subjects. Sonography appeared to detect petroleum products-induced hepatic toxicity more than biochemical assays suggesting that biochemical assessment may have underestimated toxicity.
Authors: Wolfgang Kratzer; Violetta Fritz; Richard A Mason; Mark M Haenle; Volker Kaechele Journal: J Ultrasound Med Date: 2003-11 Impact factor: 2.153
Authors: Emily J Werder; Juliane I Beier; Dale P Sandler; Keith C Falkner; Tyler Gripshover; Banrida Wahlang; Lawrence S Engel; Matthew C Cave Journal: Food Chem Toxicol Date: 2020-03-20 Impact factor: 6.023