Literature DB >> 2902627

Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.

J Lem1, A C Chin, M J Thayer, R J Leach, R E Fournier.   

Abstract

Tissue-specific extinguisher-1 (Tse-1) is a mouse genetic locus that can repress liver-specific tyrosine aminotransferase gene expression in trans. To search for other Tse-1-responsive genes, hepatoma microcell hybrids retaining mouse chromosome 11 or human chromosome 17, containing murine Tse-1 and human TSE1, respectively, were screened for expression of liver-specific mRNAs. While most liver gene activity was unaffected in such hybrids, phosphoenolpyruvate carboxykinase and tyrosine aminotransferase gene expression was coordinately repressed in these clones. Extinction of both genes was apparently mediated by a single genetic locus that resides on human chromosome 17.

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Year:  1988        PMID： 2902627      PMCID： PMC282174          DOI： 10.1073/pnas.85.19.7302

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  40 in total

1.  Expression of differentiated functions in hepatoma cell hybrids: IX extinction and reexpression of liver-specific enzymes in rat hepatoma-Chinese hamster fibroblast hybrids.

Authors:  M C Weiss; R S Sparkes; R Bertolotti
Journal:  Somatic Cell Genet       Date:  1975-01

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Authors:  G M Wahl; M Stern; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

Review 4.  Gene expression in somatic cell hybrids.

Authors:  R L Davidson
Journal:  Annu Rev Genet       Date:  1974       Impact factor: 16.830

5.  Expression of differentiated functions in hepatoma cell hybrids: alanine aminotransferase.

Authors:  R S Sparkes; M C Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1973-02       Impact factor: 11.205

6.  Expression of differentiated functions in hepatoma cell hybrids: induction of mouse albumin production in rat hepatoma-mouse fibroblast hybrids.

Authors:  J A Peterson; M C Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

7.  Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization.

Authors:  R L Davidson; B Ephrussi; K Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1966-11       Impact factor: 11.205

8.  Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain.

Authors:  M L Chu; J C Myers; M P Bernard; J F Ding; F Ramirez
Journal:  Nucleic Acids Res       Date:  1982-10-11       Impact factor: 16.971

9.  Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome.

Authors:  C Kozak; E Nichols; F H Ruddle
Journal:  Somatic Cell Genet       Date:  1975-10

10.  Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes.

Authors:  M C Weiss; M Chaplain
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205
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  15 in total

1.  Functional expression of human and mouse low density lipoprotein receptors in hybridomas.

Authors:  Y Shintani; K Iwamoto; K Kitano
Journal:  Cytotechnology       Date:  1995-01       Impact factor: 2.058

2.  Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region.

Authors:  E Ben-Shushan; E Pikarsky; A Klar; Y Bergman
Journal:  Mol Cell Biol       Date:  1993-02       Impact factor: 4.272

3.  Hormonal regulation of TSE1-repressed genes: evidence for multiple genetic controls in extinction.

Authors:  M J Thayer; R E Fournier
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

4.  Tse-2: a trans-dominant extinguisher of albumin gene expression in hepatoma hybrid cells.

Authors:  A C Chin; R E Fournier
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

Review 5.  Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver.

Authors:  F P Lemaigre; G G Rousseau
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

6.  Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex.

Authors:  M Casey; C J Vaughan; J He; C J Hatcher; J M Winter; S Weremowicz; K Montgomery; R Kucherlapati; C C Morton; C T Basson
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

7.  Extinction of retinol-binding protein gene expression in somatic cell-hybrids: identification of the target sequences.

Authors:  R Faraonio; M Musy; V Colantuoni
Journal:  Nucleic Acids Res       Date:  1990-12-25       Impact factor: 16.971

8.  Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.

Authors:  K Overturf; M al-Dhalimy; C N Ou; M Finegold; M Grompe
Journal:  Am J Pathol       Date:  1997-11       Impact factor: 4.307

9.  Extinction of phosphoenolpyruvate carboxykinase gene expression is associated with loss of a specific chromatin-binding protein from a far upstream domain.

Authors:  Y T Ip; R E Fournier; R Chalkley
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

10.  Regulation of chimeric phosphoenolpyruvate carboxykinase genes by the trans-dominant locus TSE1.

Authors:  M J Thayer; T G Lugo; R J Leach; R E Fournier
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272
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