| Literature DB >> 2902496 |
Abstract
Patients with critical coronary stenoses or hypertrophied ventricles have impaired coronary vasodilator reserve and are at greatest risk of myocardial ischaemia or infarction if subendocardial perfusion pressure falls below the lower threshold of bloodflow autoregulation. During sleep, antihypertensive treatment may cause coronary artery perfusion pressure to fall below these limits in such patients. Unrecognised nocturnal hypotension may be one reason why treatment has not diminished the risk of myocardial infarction in patients with hypertension.Entities:
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Year: 1988 PMID: 2902496 DOI: 10.1016/s0140-6736(88)90745-3
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321