S C Rosenkranz1,2, B Kaulen1,2, A Neuhaus3, S Siemonsen4, S Köpke5, M Daumer3, J-P Stellmann1,2, C Heesen1,2. 1. Institut für Neuroimmunologie und Multiple Sklerose, Zentrum für Molekulare Neurobiologie, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 2. Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 3. Sylvia Lawry Centre for Multiple Sclerosis Research, München, Germany. 4. Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 5. Institute for Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany.
Abstract
BACKGROUND AND PURPOSE: New diagnostic criteria of multiple sclerosis (MS) increase the number of patients being diagnosed with MS whilst a substantial part might not convert to clinically definite MS (CDMS). The diagnostic accuracy of the McDonald 2005 and 2010 criteria for conversion to CDMS was evaluated in an unselected cohort of patients in whom an MS diagnostic work-up was decided. METHODS: Clinical, magnetic resonance imaging and cerebrospinal fluid data were analysed for all patients who presented with symptoms suspicious for MS at the university based MS outpatient clinic between 2006 and 2010 (n = 165). RESULTS: Follow-up was available for 131 patients. During the mean follow-up period of 2 years, 19% of patients developed CDMS whereas 64% of the patients fulfilling McDonald 2010 criteria did not convert to CDMS. CONCLUSION: The low clinical conversion rate indicates that the new diagnostic criteria may increase the incidence of MS cases with a less active disease course.
BACKGROUND AND PURPOSE: New diagnostic criteria of multiple sclerosis (MS) increase the number of patients being diagnosed with MS whilst a substantial part might not convert to clinically definite MS (CDMS). The diagnostic accuracy of the McDonald 2005 and 2010 criteria for conversion to CDMS was evaluated in an unselected cohort of patients in whom an MS diagnostic work-up was decided. METHODS: Clinical, magnetic resonance imaging and cerebrospinal fluid data were analysed for all patients who presented with symptoms suspicious for MS at the university based MS outpatient clinic between 2006 and 2010 (n = 165). RESULTS: Follow-up was available for 131 patients. During the mean follow-up period of 2 years, 19% of patients developed CDMS whereas 64% of the patients fulfilling McDonald 2010 criteria did not convert to CDMS. CONCLUSION: The low clinical conversion rate indicates that the new diagnostic criteria may increase the incidence of MS cases with a less active disease course.
Authors: Roos M van der Vuurst de Vries; Julia Y Mescheriakova; Yu Yi M Wong; Tessel F Runia; Naghmeh Jafari; Johnny P Samijn; Janet W K de Beukelaar; Beatrijs H A Wokke; Theodora A M Siepman; Rogier Q Hintzen Journal: JAMA Neurol Date: 2018-11-01 Impact factor: 18.302
Authors: X Armoiry; A Kan; G J Melendez-Torres; R Court; P Sutcliffe; P Auguste; J Madan; C Counsell; A Clarke Journal: J Neurol Date: 2018-01-22 Impact factor: 4.849
Authors: Nicole Krause; Karin Riemann-Lorenz; Tanja Steffen; Anne Christin Rahn; Jana Pöttgen; Jan-Patrick Stellmann; Sascha Köpke; Tim Friede; Andrea Icks; Markus Vomhof; Herbert Temmes; Markus van de Loo; Stefan M Gold; Christoph Heesen Journal: BMJ Open Date: 2021-02-16 Impact factor: 2.692