Kamal Eldin Ahmed Abdelsalam1, Abdelsamee Alobeid M Elamin2. 1. Department of Chemical Pathology, College of Applied Medical Sciences, Shaqra University, Saudi Arabia. 2. Department of Clinical Biochemistry, College of Applied Medical Sciences, Shaqra University, Saudi Arabia.
Abstract
OBJECTIVE: It is to compare the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity. METHODOLOGY: Fasting blood samples were collected from 100 non-pregnant ladies as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Glucose (FBS) and insulin (FSI) concentrations were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure. Insulin resistance was calculated following the formula: FBG (mg dL-1)×FSI (μU mL-1)/405. RESULTS: This study found a significant reduction in glucose level in primiparity when compared to control group but it was increased significantly in multiparity comparing to primiparity and control. Insulin level showed significant high concentrations in pregnant women and increased significantly in grand multiparas comparing to primiparas and controls. As a result of that, HOMA-IR was increased significantly by increasing of parity. Also, there was a significant increase in fasting insulin and a decrease in insulin sensitivity with parity with association to age and obesity. CONCLUSION: Grand multiparity is associated with an increased risk of subsequent clinical insulin resistance (HOMA-IR).
OBJECTIVE: It is to compare the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity. METHODOLOGY: Fasting blood samples were collected from 100 non-pregnant ladies as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Glucose (FBS) and insulin (FSI) concentrations were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure. Insulin resistance was calculated following the formula: FBG (mg dL-1)×FSI (μU mL-1)/405. RESULTS: This study found a significant reduction in glucose level in primiparity when compared to control group but it was increased significantly in multiparity comparing to primiparity and control. Insulin level showed significant high concentrations in pregnant women and increased significantly in grand multiparas comparing to primiparas and controls. As a result of that, HOMA-IR was increased significantly by increasing of parity. Also, there was a significant increase in fasting insulin and a decrease in insulin sensitivity with parity with association to age and obesity. CONCLUSION: Grand multiparity is associated with an increased risk of subsequent clinical insulin resistance (HOMA-IR).
Entities:
Keywords:
Grand multiparity; HOMA-IR; glucose; insulin; nulliparity; primiparity
Authors: J B Bae; D M Lipnicki; J W Han; P S Sachdev; T H Kim; K P Kwak; B J Kim; S G Kim; J L Kim; S W Moon; J H Park; S-H Ryu; J C Youn; D Y Lee; D W Lee; S B Lee; J J Lee; J H Jhoo; I Skoog; J Najar; T R Sterner; N Scarmeas; M Yannakoulia; E Dardiotis; S Riedel-Heller; S Roehr; A Pabst; D Ding; Q Zhao; X Liang; A Lobo; C De-la-Cámara; E Lobo; K W Kim Journal: Epidemiol Psychiatr Sci Date: 2020-10-20 Impact factor: 6.892
Authors: Rafael B Galvão; Renato T Souza; Matias C Vieira; Dharmintra Pasupathy; Jussara Mayrink; Francisco E Feitosa; Edilberto A Rocha Filho; Débora F Leite; Janete Vettorazzi; Iracema M Calderon; Maria H Sousa; Jose G Cecatti Journal: BMC Pregnancy Childbirth Date: 2022-08-04 Impact factor: 3.105