Y Fouks1,2, S Amit3, A Many1,2, A Haham2,4, D Mandel2,4, S Shinar1,2. 1. Department of Obstetrics and Gynecology, Lis Maternity Hospital, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel. 2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. The Department of Clinical Microbiology and Infectious Disease, Hadassah University Hospital, Jerusalem, Israel. 4. Neonatal Intensive Care Unit, Dana Dwek Children's Hospital, Tel Aviv, Israel.
Abstract
OBJECTIVE: To compare the symptomatology of pregnant women with suspected listeriosis to culture confirmed listeriosis. STUDY DESIGN: All cases of suspected and culture confirmed pregnancy-associated listeriosis from a single center were retrospectively reviewed assessing demographics, clinical, laboratory and pathological findings, and maternal, fetal and neonatal outcomes. RESULTS: Listeriosis was identified in seven patients, none of whom belonged to the 117 women with suspected listeriosis. Women with confirmed infection were more likely to exhibit fever (P=0.01), flu-like symptoms (P=0.006), threatened preterm labor (P=0.05) and inflammatory markers (P=0.02), but less likely to exhibit gastrointestinal complaints (P=0.004) in comparison with suspected non-confirmed cases. Confirmed cases resulted in preterm delivery (n=5) and stillbirth (n=2). Neonatal complications included meningitis, respiratory disease and sepsis. Maternal outcomes were favorable. CONCLUSION: Although 'febrile gastroenteritis' is a poor predictor of listeriosis in pregnancy, fever, premature contractions and inflammatory markers are important risk indices prompting workup and adequate empiric treatment.
OBJECTIVE: To compare the symptomatology of pregnant women with suspected listeriosis to culture confirmed listeriosis. STUDY DESIGN: All cases of suspected and culture confirmed pregnancy-associated listeriosis from a single center were retrospectively reviewed assessing demographics, clinical, laboratory and pathological findings, and maternal, fetal and neonatal outcomes. RESULTS: Listeriosis was identified in seven patients, none of whom belonged to the 117 women with suspected listeriosis. Women with confirmed infection were more likely to exhibit fever (P=0.01), flu-like symptoms (P=0.006), threatened preterm labor (P=0.05) and inflammatory markers (P=0.02), but less likely to exhibit gastrointestinal complaints (P=0.004) in comparison with suspected non-confirmed cases. Confirmed cases resulted in preterm delivery (n=5) and stillbirth (n=2). Neonatal complications included meningitis, respiratory disease and sepsis. Maternal outcomes were favorable. CONCLUSION: Although 'febrile gastroenteritis' is a poor predictor of listeriosis in pregnancy, fever, premature contractions and inflammatory markers are important risk indices prompting workup and adequate empiric treatment.
Authors: Ronald F Lamont; Jack Sobel; Shali Mazaki-Tovi; Juan Pedro Kusanovic; Edi Vaisbuch; Sun Kwon Kim; Niels Uldbjerg; Roberto Romero Journal: J Perinat Med Date: 2011-04-25 Impact factor: 1.901
Authors: Eleftherios Mylonakis; Maria Paliou; Elizabeth L Hohmann; Stephen B Calderwood; Edward J Wing Journal: Medicine (Baltimore) Date: 2002-07 Impact factor: 1.889
Authors: Kristina M Angelo; Kelly A Jackson; Karen K Wong; Robert M Hoekstra; Brendan R Jackson Journal: Clin Infect Dis Date: 2016-08-17 Impact factor: 9.079
Authors: Benjamin J Silk; Kashmira A Date; Kelly A Jackson; Régis Pouillot; Kristin G Holt; Lewis M Graves; Kanyin L Ong; Sharon Hurd; Rebecca Meyer; Ruthanne Marcus; Beletshachew Shiferaw; Dawn M Norton; Carlota Medus; Shelley M Zansky; Alicia B Cronquist; Olga L Henao; Timothy F Jones; Duc J Vugia; Monica M Farley; Barbara E Mahon Journal: Clin Infect Dis Date: 2012-06 Impact factor: 9.079
Authors: Bryce Wolfe; Andrea R Kerr; Andres Mejia; Heather A Simmons; Charles J Czuprynski; Thaddeus G Golos Journal: Front Microbiol Date: 2019-09-11 Impact factor: 5.640