Literature DB >> 29022793

Intralesional excision with topical intralesional cryotherapy improves the treatment of keloid scarring in a paediatric patient.

D Reissis1, T Tickunas1, R A Agha1, Avh Greig1.   

Abstract

Recurrent keloid scarring has a significant impact on quality of life. Management is complex, particularly for scars resistant to conventional treatments and in paediatric cases where radiotherapy is not a suitable adjunct to surgical excision. We present the case of a nine-year-old African Caribbean girl with multiple large and recurrent keloid scars on both ears and bilateral sensorineural deafness. Following repeated intralesional excisions, corticosteroid and botulinum toxin injections, she continued to experience rapid recurrence of her keloids, worsening pain and pruritus. She was no longer able to wear her hearing aids because of the large size of the keloids. We employed a novel technique using topical intralesional cryotherapy, applying liquid nitrogen intraoperatively to the inside of the skin flaps immediately post-intralesional keloid excision and before wound closure. At 26-month follow-up a good aesthetic and symptomatic result was achieved, with minimal hypopigmentation, significantly reduced scar volume and significantly slowed recurrence. We discuss this case and review the current literature on the use of topical intralesional cryotherapy for keloid scarring.

Entities:  

Keywords:  Cryotherapy; Intralesional cryotherapy; Keloid

Mesh:

Year:  2017        PMID: 29022793      PMCID: PMC5696934          DOI: 10.1308/rcsann.2017.0156

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  5 in total

1.  Cryotherapy modifies synthetic activity and differentiation of keloidal fibroblasts in vitro.

Authors:  A Dalkowski; S Fimmel; C Beutler; Ch C Zouboulis
Journal:  Exp Dermatol       Date:  2003-10       Impact factor: 3.960

Review 2.  Novel Insights on Understanding of Keloid Scar: Article Review.

Authors:  Walid Mari; Sami G Alsabri; Najib Tabal; Sara Younes; Abdulamagid Sherif; Richard Simman
Journal:  J Am Coll Clin Wound Spec       Date:  2016-11-30

3.  Updated international clinical recommendations on scar management: part 2--algorithms for scar prevention and treatment.

Authors:  Michael H Gold; Michael McGuire; Thomas A Mustoe; Andrea Pusic; Mukta Sachdev; Jill Waibel; Crystal Murcia
Journal:  Dermatol Surg       Date:  2014-08       Impact factor: 3.398

Review 4.  Intralesional Cryotherapy for the Treatment of Keloid Scars: Evaluating Effectiveness.

Authors:  Michiel C E van Leeuwen; Anne Eva J Bulstra; Johannes C F Ket; Marco J P F Ritt; Paul A M van Leeuwen; Frank B Niessen
Journal:  Plast Reconstr Surg Glob Open       Date:  2015-07-08

5.  Cryotherapy in treatment of keloids: evaluation of factors affecting treatment outcome.

Authors:  Meenu Barara; Vibhu Mendiratta; Ram Chander
Journal:  J Cutan Aesthet Surg       Date:  2012-07
  5 in total
  2 in total

1.  Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial.

Authors:  Ke Deng; Haitao Xiao; Xiaoxue Liu; Rei Ogawa; Xuewen Xu; Yong Liu
Journal:  PLoS One       Date:  2021-03-23       Impact factor: 3.240

Review 2.  Diagnosis and Treatment of Keloids and Hypertrophic Scars-Japan Scar Workshop Consensus Document 2018.

Authors:  Rei Ogawa; Sadanori Akita; Satoshi Akaishi; Noriko Aramaki-Hattori; Teruyuki Dohi; Toshihiko Hayashi; Kazuo Kishi; Taro Kono; Hajime Matsumura; Gan Muneuchi; Naoki Murao; Munetomo Nagao; Keisuke Okabe; Fumiaki Shimizu; Mamiko Tosa; Yasuyoshi Tosa; Satoko Yamawaki; Shinichi Ansai; Norihisa Inazu; Toshiko Kamo; Reiko Kazki; Shigehiko Kuribayashi
Journal:  Burns Trauma       Date:  2019-12-27
  2 in total

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