Literature DB >> 29022719

The Protein Corona of PEGylated PGMA-Based Nanoparticles is Preferentially Enriched with Specific Serum Proteins of Varied Biological Function.

Priya S R Naidu, Marck Norret, Nicole M Smith, Sarah A Dunlop, Nicolas L Taylor, Melinda Fitzgerald1, K Swaminathan Iyer.   

Abstract

The composition of the protein corona formed on poly(ethylene glycol)-functionalized (PEGylated) poly(glycidyl methacrylate) (PGMA) nanoparticles (NPs) was qualitatively and quantitatively compared to the protein corona on non-PEGylated PGMA NPs. Despite the reputation of PEGylated NPs for stealth functionality, we demonstrate the preferential enrichment of specific serum proteins of varied biological function in the protein corona on PEGylated NPs when compared to non-PEGylated NPs. Additionally, we suggest that the base material of polymeric NPs plays a role in the preferential enrichment of select serum proteins to the hard corona.

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Year:  2017        PMID： 29022719     DOI： 10.1021/acs.langmuir.7b02568

Source DB:  PubMed          Journal:  Langmuir        ISSN： 0743-7463            Impact factor:   3.882


  6 in total

1.  Concentration and composition of the protein corona as a function of incubation time and serum concentration: an automated approach to the protein corona.

Authors:  Karsten M Poulsen; Christine K Payne
Journal:  Anal Bioanal Chem       Date:  2022-08-26       Impact factor: 4.478

2.  Protein corona formation moderates the release kinetics of ion channel antagonists from transferrin-functionalized polymeric nanoparticles.

Authors:  Priya S R Naidu; Eleanor Denham; Carole A Bartlett; Terry McGonigle; Nicolas L Taylor; Marck Norret; Nicole M Smith; Sarah A Dunlop; K Swaminathan Iyer; Melinda Fitzgerald
Journal:  RSC Adv       Date:  2020-01-15       Impact factor: 4.036

Review 3.  Isolation methods for particle protein corona complexes from protein-rich matrices.

Authors:  Linda Böhmert; Linn Voß; Valerie Stock; Albert Braeuning; Alfonso Lampen; Holger Sieg
Journal:  Nanoscale Adv       Date:  2020-01-09

4.  Physicochemical Characterization of FRET-Labelled Chitosan Nanocapsules and Model Degradation Studies.

Authors:  Stefan Hoffmann; Christian Gorzelanny; Bruno Moerschbacher; Francisco M Goycoolea
Journal:  Nanomaterials (Basel)       Date:  2018-10-17       Impact factor: 5.076

5.  Novel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells.

Authors:  Priya S R Naidu; Marck Norret; Sarah A Dunlop; Melinda Fitzgerald; Tristan D Clemons; K Swaminathan Iyer
Journal:  ACS Omega       Date:  2019-10-11

6.  Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio-Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines.

Authors:  Kuo-Ching Mei; Artur Ghazaryan; Er Zhen Teoh; Huw D Summers; Yueting Li; Belén Ballesteros; Justyna Piasecka; Adam Walters; Robert C Hider; Volker Mailänder; Khuloud T Al-Jamal
Journal:  Adv Mater       Date:  2018-08-24       Impact factor: 30.849
  6 in total

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