Vanessa Bianconi 1 , Francesca Fallarino 2 , Massimo Raffaele Mannarino 1 , Francesco Bagaglia 1 , Meisam Naeimi Kararoudi 1 , Caterina Oriana Aragona 3 , Rita Romani 4 , Matteo Pirro 1 Show Affiliations »
Abstract
BACKGROUND: Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions, with experimental and clinical studies indicating a therapeutic potential for proangiogenic cells (PCs), including endothelial progenitor cells, in the treatment of coronary and peripheral artery disease. OBJECTIVE: To provide a summary of the therapeutic potential of PCs administration or mobilization in peripheral artery disease, ischemic heart and cerebrovascular diseases, diabetic microvascular complications and inflammatory rheumatic diseases. METHODS: We undertook a search of bibliographic databases for peer-reviewed research literature on the role of PCs in vascular regeneration in preclinical and clinical models. RESULTS: Improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, in this setting, contrasting results from meta-analyses question the long-term clinical efficacy of PC-based approaches. Preclinical studies and clinical trials support the safety and feasibility of PC therapy in the treatment of ischemic heart and cerebrovascular diseases, while evidence indicating a benefit on hard clinical outcomes is uncertain. Despite accumulating experimental results support a therapeutic role for PCs in diabetic retinopathy, results from randomized clinical trials are lacking. Whether PC therapy may limit premature atherosclerosis and reduce cardiovascular risk in inflammatory rheumatic diseases needs to be investigated. CONCLUSION: Although the potential clinical applications of PCs are accumulating, there is also evidence of multiple limitations for autologous PC therapy. Thus, novel strategies aimed at improving PC viability and angiogenic function are warranted in order to improve the efficacy of cell therapy applications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions, with experimental and clinical studies indicating a therapeutic potential for proangiogenic cells (PCs ), including endothelial progenitor cells, in the treatment of coronary and peripheral artery disease . OBJECTIVE: To provide a summary of the therapeutic potential of PCs administration or mobilization in peripheral artery disease , ischemic heart and cerebrovascular diseases , diabetic microvascular complications and inflammatory rheumatic diseases . METHODS: We undertook a search of bibliographic databases for peer-reviewed research literature on the role of PCs in vascular regeneration in preclinical and clinical models. RESULTS: Improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia . However, in this setting, contrasting results from meta-analyses question the long-term clinical efficacy of PC -based approaches. Preclinical studies and clinical trials support the safety and feasibility of PC therapy in the treatment of ischemic heart and cerebrovascular diseases , while evidence indicating a benefit on hard clinical outcomes is uncertain. Despite accumulating experimental results support a therapeutic role for PCs in diabetic retinopathy , results from randomized clinical trials are lacking. Whether PC therapy may limit premature atherosclerosis and reduce cardiovascular risk in inflammatory rheumatic diseases needs to be investigated. CONCLUSION: Although the potential clinical applications of PCs are accumulating, there is also evidence of multiple limitations for autologous PC therapy. Thus, novel strategies aimed at improving PC viability and angiogenic function are warranted in order to improve the efficacy of cell therapy applications. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Keywords:
Proangiogenic cells; cell therapy; cerebrovascular disease; diabetes; endothelial progenitor cells; heartzzm321990failure; inflammation; ischemic heart disease; microvascular; peripheral artery disease; rheumatic disease.
Mesh： See more »
Year: 2018
PMID： 29022506 DOI： 10.2174/0929867324666171012111603
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530