Aniruddha Agarwal1, Rupesh Agrawal2,3,4, Neha Khandelwal2, Alessandro Invernizzi5, Kanika Aggarwal1, Aman Sharma6, Ramandeep Singh1, Reema Bansal1, Kusum Sharma7, Nirbhai Singh1, Vishali Gupta1. 1. a Advanced Eye Center, Post Graduate Institute of Medical Education and Research , Chandigarh , India. 2. b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore. 3. c Singapore Eye Research Institute and Singapore National Eye Centre , Singapore. 4. d Moorfields Eye Hospital, NHS Foundation Trust , London , UK. 5. e Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco" , Luigi Sacco Hospital, University of Milan , Milan , Italy. 6. f Department of Internal Medicine, Division of Rheumatology , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India. 7. g Department of Microbiology, Division of Mycobacteriology , Post Graduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India.
Abstract
PURPOSE: To assess choroidal vascular changes among patients with tubercular multifocal serpiginoid choroiditis (TB MSC) using previously validated techniques. METHODS: Patients with TB MSC (n = 18) and healthy controls (n = 30) underwent enhanced-depth imaging optical coherence tomography (EDI-OCT) imaging. Using previously validated algorithm of image binarization, EDI-OCT scans were segmented to derive total choroidal area, luminal area, stromal area, and choroidal vascularity index (CVI). RESULTS: There was a statistically significant difference in the CVI between controls (66.90 ± 1.77%) and TB MSC patients (65.46 ± 2.53%; p < 0.001). There was significant reduction in CVI at follow-up (3 months) (63.77 ± 3.91%; p = 0.05). The choroidal thickness was higher in TB MSC compared to controls (278.90 ± 57.84 µm versus 329.33 ± 27.69 µm; p = 0.001). CONCLUSIONS: CVI provides insight into structural changes in choroid in TB MSC. During the active disease, there is relative decrease in choroidal vascularity. As the lesions heal, choriocapillaris atrophy occurs with remodeling of choroid.
PURPOSE: To assess choroidal vascular changes among patients with tubercular multifocal serpiginoid choroiditis (TB MSC) using previously validated techniques. METHODS:Patients with TB MSC (n = 18) and healthy controls (n = 30) underwent enhanced-depth imaging optical coherence tomography (EDI-OCT) imaging. Using previously validated algorithm of image binarization, EDI-OCT scans were segmented to derive total choroidal area, luminal area, stromal area, and choroidal vascularity index (CVI). RESULTS: There was a statistically significant difference in the CVI between controls (66.90 ± 1.77%) and TB MSC patients (65.46 ± 2.53%; p < 0.001). There was significant reduction in CVI at follow-up (3 months) (63.77 ± 3.91%; p = 0.05). The choroidal thickness was higher in TB MSC compared to controls (278.90 ± 57.84 µm versus 329.33 ± 27.69 µm; p = 0.001). CONCLUSIONS: CVI provides insight into structural changes in choroid in TB MSC. During the active disease, there is relative decrease in choroidal vascularity. As the lesions heal, choriocapillaris atrophy occurs with remodeling of choroid.
Authors: Hao Zhou; Yining Dai; Yingying Shi; Jonathan F Russell; Cancan Lyu; Jila Noorikolouri; William J Feuer; Zhongdi Chu; Qinqin Zhang; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Ophthalmol Retina Date: 2019-10-01