| Literature DB >> 29020526 |
Antonio Ivanildo Pinho1, Cláudia Sirlene Oliveira1, Fabricio Luís Lovato1, Emily Pansera Waczuk1, Bruna Candia Piccoli1, Aline Augusti Boligon2, Nadghia Figueredo Leite3, Henrique Douglas Melo Coutinho3, Thais Posser1,4, João Batista Teixeira Da Rocha1, Jeferson Luis Franco1,4.
Abstract
Mercury (Hg) is widely distributed in the environment and is known to produce several adverse effects in organisms. The aim of the present study was to examine the in vitro antioxidant activity and Hg chelating ability of the hydroalcoholic extract of Psidium guajava leaves (HEPG). In addition, the potential protective effects of HEPG against Hg(II) were evaluated using a yeast model (Saccharomyces cerevisiae). HEPG was found to exert significant antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenger and inhibition of lipid peroxidation induced by Fe(II) assays in a concentration-dependent manner. The extract also exhibited significant Hg(II) chelating activity. In yeast, Hg(II) induced a significant decrease in cell viability. In contrast, HEPG partially prevented the fall in cell viability induced by Hg(II). In conclusion, HEPG exhibited protective effects against Hg(II)-mediated toxicity, which may be related to both antioxidant and Hg(II)-chelating activities.Entities:
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Year: 2017 PMID： 29020526 DOI： 10.1080/15287394.2017.1382408
Source DB: PubMed Journal: J Toxicol Environ Health A ISSN： 0098-4108