Literature DB >> 29020162

Successful Therapy of a Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing and Fluoroquinolone-Resistant Salmonella enterica Subspecies enterica Serovar Typhi Infection Using Combination Therapy of Meropenem and Fosfomycin.

Carola-Ellen Kleine1,2, Stefan Schlabe1,2, Gunnar T R Hischebeth2,3, Ernst Molitor2,3, Yvonne Pfeifer4, Jan-Christian Wasmuth1,2, Ulrich Spengler1,2.   

Abstract

We report a traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against β-lactams, cephalosporins (extended-spectrum β-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7). After clinical deterioration using meropenem monotherapy, treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multidrug-resistant S. Typhi.
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  S. Typhi; antibiotic resistance; carbapenems; enteric fever; fosfomycin

Mesh:

Substances:

Year:  2017        PMID: 29020162     DOI: 10.1093/cid/cix652

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  7 in total

1.  Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins.

Authors:  Elizabeth J Klemm; Sadia Shakoor; Gordon Dougan; Rumina Hasan; Andrew J Page; Farah Naz Qamar; Kim Judge; Dania K Saeed; Vanessa K Wong; Timothy J Dallman; Satheesh Nair; Stephen Baker; Ghazala Shaheen; Shahida Qureshi; Mohammad Tahir Yousafzai; Muhammad Khalid Saleem; Zahra Hasan
Journal:  MBio       Date:  2018-02-20       Impact factor: 7.867

2.  Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults.

Authors:  Niv Zmora; Sudeep Shrestha; Ami Neuberger; Yael Paran; Rajendra Tamrakar; Ashish Shrestha; Surendra K Madhup; T R S Bedi; Rajendra Koju; Eli Schwartz
Journal:  PLoS Negl Trop Dis       Date:  2018-04-23

3.  The epidemiology of typhoid fever in the Dhulikhel area, Nepal: A prospective cohort study.

Authors:  Neta Petersiel; Sudeep Shresta; Rajendra Tamrakar; Rajendra Koju; Surendra Madhup; Ashish Shresta; Trs Bedi; Niv Zmora; Yael Paran; Eli Schwartz; Ami Neuberger
Journal:  PLoS One       Date:  2018-09-27       Impact factor: 3.240

Review 4.  Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever.

Authors:  Christian G Blumentrath; Gernot Müller; Dieter Teichmann; Jens Tiesmeier; Jasmina Petridou
Journal:  Ger Med Sci       Date:  2019-01-07

5.  Genomic surveillance detects Salmonella enterica serovar Paratyphi A harbouring blaCTX-M-15 from a traveller returning from Bangladesh.

Authors:  Satheesh Nair; Martin Day; Gauri Godbole; Tranprit Saluja; Gemma C Langridge; Timothy J Dallman; Marie Chattaway
Journal:  PLoS One       Date:  2020-01-30       Impact factor: 3.240

Review 6.  A Phage Therapy Guide for Clinicians and Basic Scientists: Background and Highlighting Applications for Developing Countries.

Authors:  Ali Khalid; Ruby C Y Lin; Jonathan R Iredell
Journal:  Front Microbiol       Date:  2021-02-11       Impact factor: 5.640

7.  Response of extensively drug resistant Salmonella Typhi to treatment with meropenem and azithromycin, in Pakistan.

Authors:  Sonia Qureshi; Abdullah B Naveed; Mohammad Tahir Yousafzai; Khalil Ahmad; Sarwat Ansari; Heeramani Lohana; Aimen Mukhtar; Farah Naz Qamar
Journal:  PLoS Negl Trop Dis       Date:  2020-10-15
  7 in total

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