| Literature DB >> 29020162 |
Carola-Ellen Kleine1,2, Stefan Schlabe1,2, Gunnar T R Hischebeth2,3, Ernst Molitor2,3, Yvonne Pfeifer4, Jan-Christian Wasmuth1,2, Ulrich Spengler1,2.
Abstract
We report a traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against β-lactams, cephalosporins (extended-spectrum β-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7). After clinical deterioration using meropenem monotherapy, treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multidrug-resistant S. Typhi.Entities:
Keywords: S. Typhi; antibiotic resistance; carbapenems; enteric fever; fosfomycin
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Year: 2017 PMID: 29020162 DOI: 10.1093/cid/cix652
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079