Literature DB >> 2901974

5-Methyl-urapidil discriminates between subtypes of the alpha 1-adrenoceptor.

G Gross1, G Hanft, C Rugevics.   

Abstract

The affinity of 5-methyl-urapidil for alpha 1-adrenoceptors was determined from the inhibition of [3H]prazosin binding on membrane of different rat tissues. In hippocampus, vas deferens and heart 5-methyl-urapidil displaced [3H]prazosin in a biphasic manner with mean pKI values between 9.1 and 9.4 for the high-affinity site and 7.2 to 7.8 for the low-affinity site. Only the low affinity site was found in spleen and liver. At present, 5-methyl-urapidil is the antagonist which most clearly discriminates between alpha 1-adrenoceptor subtypes.

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Year:  1988        PMID： 2901974     DOI： 10.1016/0014-2999(88)90819-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  42 in total

1.  Identification of a single alpha 1-adrenoceptor corresponding to the alpha 1A-subtype in rat submaxillary gland.

Authors:  A D Michel; D N Loury; R L Whiting
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

2.  Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine.

Authors:  Zhilin Song; Dayane A Gomes; Wanida Stevens; Celia D Sladek
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-09-29       Impact factor: 3.619

3.  Alpha 1 B- but not alpha 1 A-adrenoceptors mediate inositol phosphate generation.

Authors:  M C Michel; G Hanft; G Gross
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

4.  alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries.

Authors:  Ravi Goyal; Ashwani Mittal; Nina Chu; Lubo Zhang; Lawrence D Longo
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-03-26       Impact factor: 4.733

Review 5.  Cardiac alpha(1)-adrenoceptors that regulate contractile function: subtypes and subcellular signal transduction mechanisms.

Authors:  M Endoh
Journal:  Neurochem Res       Date:  1996-02       Impact factor: 3.996

Review 6.  Classification of alpha 1-adrenoceptor subtypes.

Authors:  M C Michel; B Kenny; D A Schwinn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-07       Impact factor: 3.000

7.  Characterization of alpha 1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation.

Authors:  J H Guh; S C Chueh; F N Ko; C M Teng
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

8.  Comparison of guinea-pig, bovine and rat alpha 1-adrenoceptor subtypes.

Authors:  R Büscher; C Heeks; K Taguchi; M C Michel
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

9.  Evidence for a noradrenergic innervation to alpha 1A-adrenoceptors in rat kidney.

Authors:  D R Blue; R L Vimont; D E Clarke
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

10.  Role of alpha 1A adrenoceptor subtype in production of the positive inotropic effect mediated via myocardial alpha 1 adrenoceptors in the rabbit papillary muscle: influence of selective alpha 1A subtype antagonists WB 4101 and 5-methylurapidil.

Authors:  M Endoh; M Takanashi; I Norota
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000
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